The tissue engineering paradigm. The tissue engineering paradigm consists of isolation and proliferation of a cell source, seeding of the cells onto a scaffold, stimulation of the cell-seeded scaffold to develop a tissue equivalent, and implantation of the construct in vivo. Figure reproduced under a Creative Commons Attribution 3.0 Unported license.
Killian et al. Arthritis Research & Therapy 2012 14:214 doi:10.1186/ar3846