Microscopic findings in hemophagocytic lymphohistiocytosis and conditions predisposing to it. (a) Macrophage phagocytosing erythrocytes and erythroblast (bone marrow). (b,c) Giant granule in monocyte (bone marrow) (b) and small granules in neutrophil (peripheral blood) (c) in Chédiak Higashi syndrome (CHS). (d) Extracellular amastigotes in visceral leishmaniasis (bone marrow). (e) Pigment clumps in a hair shaft in a patient with Griscelli syndrome type II. (f) Evenly distributed melanin granules, larger as in normal hairs, in a patient with CHS. Smears are shown at 600× magnification, hair at 100×.
Bode et al. Arthritis Research & Therapy 2012 14:213 doi:10.1186/ar3843