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Highly Accessed Editorial

Statins: a revised appraisal for potential additional future treatment indications

Robert Weissert

Author affiliations

Department of Neurology, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany

Citation and License

Arthritis Research & Therapy 2012, 14:121  doi:10.1186/ar3880


See related research by Vandebriel et al., http://arthritis-research.com/content/14/2/R90

Published: 29 June 2012

Abstract

Beside statins' well established positive influence on atherosclerotic vascular disease caused by hypercholesterolemia through selective competitive inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, additional effects on the immune system have been described for them. These observations have raised great hopes for additional future treatment indications, including rheumatoid arthritis and multiple sclerosis. Ten years of searching for such novel treatment indications have not led to breakthroughs and future efforts must be seen with skepticism.