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Editorial

Approaching the immunophysiology of steroid resistance

Rick Bucala

Author Affiliations

Section of Rheumatology, Department of Medicine, Yale University School of Medicine, TAC S525, PO Box 208031, 300 Cedar Street, New Haven, CT 06520-8031, USA

Arthritis Research & Therapy 2012, 14:118  doi:10.1186/ar3820


See related research by Wang et al., http://arthritis-research.com/content/14/3/R103

Published: 18 May 2012

Abstract

Wang and colleagues have investigated a mechanistic basis for resistance to steroid therapy in systemic lupus erythematosus patients. Their examination reveals significant differences in macrophage migration inhibitory factor (MIF)-dependent expression of IκB, which is a critical cellular regulator of the broadly proinflammatory transcription factor NF-κB. Their studies also suggest that MIF may be a clinically useful biomarker in systemic lupus erythematosus and support the therapeutic targeting of MIF as a means to reduce clinical steroid resistance.