Table 2

Association results of the 25 systemic lupus erythematosus SNPs

Mantel-Haenszel analysis


SNP (locus)

OR (95% CI)

P value

Reference


rs1143679 (ITGAM)

1.70 (1.50 to 1.93)

5.16 × 10-17

[24]

rs7574865 (STAT4)

1.52 (1.36 to 1.70)

6.11 × 10-14

[24]

rs13277113 (C8orf13-BLK)

1.34 (1.20 to 1.50)

1.33 × 10-7

[24]

rs2304256 (TYK2)

1.32 (1.18 to 1.47)

1.17 × 10-6

[24]

rs17435 (MECP2)a

1.27 (1.11 to 1.45)

5.57 × 10-4

[24]

rs10798269 (1q25.1)

1.25 (1.11 to 1.39)

6.12 × 10-5

[24]

rs17266594 (BANK1)

1.23 (1.10 to 1.37)

1.92 × 10-4

[24]

rs4963128 (KIAA1542)

1.19 (1.08 to 1.32)

1.31 × 10-3

[24]

rs6445975 (PXK)

1.15 (1.03 to 1.27)

0.02

[24]

rs3131379 (MSH5)

2.25 (1.89 to 2.68)

6.41 × 10-20

-

rs2187668 (HLA-DQA1)

2.17 (1.88 to 2.51)

1.09 × 10-25

-

rs10488631 (IRF5)

2.00 (1.73 to 2.32)

8.38 × 10-21

[25]

rs2230926 (TNFAIP3)

1.99 (1.60 to 2.47)

2.54 × 10-10

-

rs729302 (IRF5)

1.35 (1.20 to 1.49)

1.70 × 10-7

[25]

rs2476601 (PTPN22)

1.34 (1.13 to 1.60)

9.15 × 10-4

-

rs5754217 (UBE2L3)

1.26 (1.13 to 1.42)

7.30 × 10-5

-

rs2205960 (TNFSF4)

1.25 (1.11 to 1.40)

1.32 × 10-4

-

rs6920220 (TNFAIP3)

1.21 (1.07 to 1.37)

2.25 × 10-3

-

rs844644 (TNFSF4)

1.19 (1.08 to 1.32)

7.22 × 10-4

-

rs1801274 (FCGR2A)

1.18 (1.07 to 1.30)

1.27 × 10-3

-

rs573775 (ATG5)

1.17 (1.05 to 1.31)

4.35 × 10-3

-

rs10156091 (ICA1)

1.09 (0.93 to 1.28)

0.3

-

rs4240671 (XKR6)

1.09 (0.98 to 1.19)

0.1

-

rs2667978 (LYN)

1.06 (0.94 to 1.19)

0.3

-

rs6922466 (PERP)

1.02 (0.91 to 1.14)

0.8

-


The first nine SNPs were analysed in the first phase of the study and the remaining 16 in the second. Results of Mantel-Haenszel analysis are shown. All odds ratios (ORs) are expressed for the risk allele. Analyses of some of the SNPs in these samples have already been reported [24,25]. CI, confidence interval. aAnalysis performed only in women because the locus is in the X chromosome.

Alonso-Perez et al. Arthritis Research & Therapy 2012 14:R94   doi:10.1186/ar3818

Open Data