Table 2

Association of four-marker rs9358890-rs3799344-rs1183201-rs12664474 haplotypes with gout

Frequency


Haplotypea

Case

Control

OR (95% CI)

P value


Caucasian

A-T-A-A

270 (0.339)

1044 (0.428)

0.66 (0.56 to 0.78)

1.5 × 10-6

A-C-T-A

327 (0.410)

876 (0.360)

1.22 (1.03 to 1.44)

0.014

A-C-T-G

121 (0.152)

284 (0.117)

1.34 (1.06 to 1.69)

0.015

G-C-T-G

47 (0.059)

104 (0.043)

1.39 (0.98 to 1.98)

0.067

EP/N

A-T-A-A

107 (0.239)

101 (0.274)

0.84 (0.61 to 1.15)

0.27

A-C-T-A

160 (0.356)

109 (0.297)

1.33 (0.99 to 1.78)

0.06

G-C-T-G

161 (0.360)

140 (0.380)

0.93 (0.70 to 1.23)

0.60

EP/Z

A-T-A-A

32 (0.372)

120 (0.414)

0.84 (0.51 to 1.38)

0.49

A-C-T-A

32 (0.372)

111 (0.384)

0.95 (0.58 to 1.56)

0.84

G-C-T-G

9 (0.105)

26 (0.090)

1.19 (0.53 to 2.64)

0.68

A-C-T-G

10 (0.116)

22 (0.075)

1.63 (0.74 to 3.59)

0.23

WP

A-C-T-A

171 (0.357)

96 (0.343)

1.07 (0.78 to 1.45)

0.70

A-T-A-A

116 (0.241)

89 (0.318)

0.68 (0.49 to 0.94)

0.021

G-C-T-G

171 (0.356)

77 (0.275)

1.46 (1.06 to 2.02)

0.021

A-C-T-G

12 (0.025)

12 (0.043)

0.57 (0.25 to 1.29)

0.17

EP/WP

A-T-A-A

5 (0.167)

16 (0.400)

0.30 (0.10 to 0.95)

0.035

A-C-T-A

15 (0.500)

13 (0.324)

2.08 (0.78 to 5.50)

0.14

G-C-T-G

6 (0.200)

11 (0.275)

0.66 (0.21 to 2.05)

0.47


CI, confidence interval; EP, Eastern Polynesian; OR, odds ratio; WP, Western Polynesian. aHaplotypes are listed in descending order of control frequency; those with frequency < 0.03 were excluded.

Hollis-Moffatt et al. Arthritis Research & Therapy 2012 14:R92   doi:10.1186/ar3816

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