Table 1

Comparison of statin effects on murine collagen-induced arthritis

Study

Statin

Dose (mg/kg)

Exposure route

Timing (days)

Effect on arthritis


Present study

A

10

Oral

-28 to 20

ΔET50 -7 days

Present study

A

10

Oral

22 to 42

ΔET50 -9 days

Present study

P

40

Oral

-28 to 20

ΔET50 -5 days

Present study

P

40

Oral

22 to 42

ΔET50 -7 days

Ho and colleagues [13]

A

10

Oral

2 to 49

Suppression

Yamagata and colleagues [14]

P

100

Intraperitoneal

0 to 35

Suppression

Leung and colleagues [15]

S

40

Intraperitoneal

21 to 40

Suppression

Leung and colleagues [15]

S

20

Intraperitoneal

21 to 40

No effect

Leung and colleagues [15]

S

10

Intraperitoneal

21 to 40

No effect

Palmer and colleagues [16]

A

100

Oral

0 to 48

No effect

Palmer and colleagues [16]

A

1

Oral

0 to 48

No effect

Palmer and colleagues [16]

R

2

Subcutaneous

0 to 48

No effect

Palmer and colleagues [16]

R

0.2

Subcutaneous

0 to 48

No effect

Palmer and colleagues [16]

R

40

Intraperitoneal

21 to 35

No effect

Palmer and colleagues [16]

S

40

Intraperitoneal

21 to 35

Suppression

Palmer and colleagues [16]

S

40

Oral

21 to 35

No effect


A, atorvastatin; P, pravastatin; S, simvastatin; R, rosuvastatin; ΔET50, number of days between the time when 50% of the animals developed arthritis (ET50 value) for the statin-treated animals and the ET50 value for the control animals.

Vandebriel et al. Arthritis Research & Therapy 2012 14:R90   doi:10.1186/ar3814

Open Data