Effect of collagen-induced arthritis induction and statin treatment on body weight. Mice were immunized at day 0, challenged at day 21, and weighed three times a week until euthanasia at day 42. Statins were given daily. Black circles connected by dotted line, atorvastatin before collagen-induced arthritis (CIA) induction; black squares connected by dotted line, atorvastatin after CIA induction; black triangles connected by dotted line, pravastatin before CIA induction; black inverted triangles connected by dotted line, pravastatin after CIA induction; black diamonds connected by dotted line, CIA control; black circles connected by continuous line, negative control. n = 12 per group. The effect of arthritis induction was assessed using an independent-samples t test; the effect of statin treatments was assessed using one-way analysis of variance, followed by the Bonferroni post hoc test.
Vandebriel et al. Arthritis Research & Therapy 2012 14:R90 doi:10.1186/ar3814