Table 2

Association of CD226 haplotype block in the Fib+ subset of systemic sclerosis patients.

rs763361

rs34794968

rs727088

Subgroup

MAF (%)

P_MH

P_Bonf

OR [CI 95%]

P_BD

Fib+

0.40

T

A

G

CTRL

0.41

0.59

NS

0.97 [0.86-1.08]

0.45

Fib-

0.41

0.76

NS

0.98 [0.86-1.11]

0.77

Fib+

0.10

T

C

G

CTRL

0.08

1.59E-02

3.18E-02

1.27 [1.05-1.54]

0.48

Fib-

0.08

0.069

NS

1.24 [0.99-1.56]

0.51

Fib+

0.50

C

C

A

CTRL

0.51

0.44

NS

0.96 [0.86-1.07]

0.71

Fib-

0.51

0.50

NS

0.95 [0.84-1.09]

0.44

For the haplotype-specific analyses, the odds ratio (OR) with 95% confidence interval (95% CI) was determined for each allele variant in the haplotype tested against all of the others pooled together using the Mantel-Haenszel test under fixed effects model, considering no single reference haplotype. CTRL, healthy controls; Fib-, lung fibrosis negative SSc patients; Fib+, lung fibrosis positive SSc patients; MAF, minor allele frequency; P_Bonf, corrected P-value using Bonferroni multiple test correction.

Bossini-Castillo et al. Arthritis Research & Therapy 2012 14:R85   doi:10.1186/ar3809