Effect of estradiol treatment on Staphylococcus aureus-induced systemic bone loss as analyzed with peripheral quantitative computed tomography (pQCT). Trabecular bone mineral density (BMD) (A), cortical BMD (B), and cortical thickness (C) in ovariectomized estradiol- and placebo-treated S. aureus-infected mice and in ovariectomized, placebo-treated, uninfected controls. Horizontal bars show median values, and each symbol represents one mouse. *P < 0.05; **P < 0.01; and ***P < 0.001; as analyzed with two-way ANOVAs with Bonferroni posttests.
Gjertsson et al. Arthritis Research & Therapy 2012 14:R76 doi:10.1186/ar3799