Research article
miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4
1 The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, China, 200025
2 Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China, 200011
3 Cell and Molecular Biology Laboratory, Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, USA, RI 02903
Arthritis Research & Therapy 2012, 14:R75 doi:10.1186/ar3798
Published: 16 April 2012Additional files
Additional file 1:
Figure S1 showing a heatmap of miRNA expression profiles of chondrocytes stimulated with IL-1β. Statistically significant miRNAs (P < 0.01, selected by analysis of variance test) are presented. Green and red denotes downregulated and upregulated expression, respectively.
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