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Open Access Highly Accessed Research article

miR-146a, an IL-1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4

Jing Li1, Jingang Huang1, Liming Dai1, Degang Yu2, Qian Chen3, Xiaoling Zhang12* and Kerong Dai12*

Author Affiliations

1 The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, China, 200025

2 Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China, 200011

3 Cell and Molecular Biology Laboratory, Department of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, USA, RI 02903

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Arthritis Research & Therapy 2012, 14:R75  doi:10.1186/ar3798

Published: 16 April 2012

Additional files

Additional file 1:

Figure S1 showing a heatmap of miRNA expression profiles of chondrocytes stimulated with IL-1β. Statistically significant miRNAs (P < 0.01, selected by analysis of variance test) are presented. Green and red denotes downregulated and upregulated expression, respectively.

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