Table 2

Percentages of cytokine-producing CCR4+ and/or CCR6+ cell subsets within the total CD4+ T cell population compared with the CCR4-CCR6- cell subset

Granulomatosis with polyangiitis

CCR4-CCR6- cells

CCR4+CCR6- cells

CCR4-CCR6+ cells

CCR4+CCR6+ cells


Percentage of IFNγ+ cells

11.3 ± 5.1

5.5 ± 2.0

28.2 ± 4.3

4.0 ± 0.5

Percentage of IL-4+ cells

1.0 ± 0.5

5.5 ± 1.5a

0.6 ± 0.3

1.0 ± 0.4

Percentage of IL-17+ cells

0.1 ± 0.0

0.1 ± 0.0

7.8 ± 1.8a

9.5 ± 0.9b

Percentage of IL-22+ cells

0.1 ± 0.0

0.2 ± 0.1

2.4 ± 0.5a

3.4 ± 0.6a

Healthy controls

CCR4-CCR6- cells

CCR4+CCR6- cells

CCR4-CCR6+ cells

CCR4+CCR6+ cells

Percentage of IFNγ+ cells

21.7 ± 8.4

13.1 ± 2.0

30.7 ± 1.1

6.0 ± 0.5

Percentage of IL-4+ cells

1.0 ± 0.3

5.4 ± 1.0a

1.5 ± 0.4

2.2 ± 0.6

Percentage of IL-17+ cells

0.1 ± 0.0

0.2 ± 0.0

9.1 ± 1.0a

9.7 ± 1.8a

Percentage of IL-22+ cells

0.1 ± 0.0

0.4 ± 0.2

3.3 ± 0.9a

5.0 ± 2.1a


Percentages of positive cells were assessed by flow cytometry. Values are expressed as mean ± standard error of the mean. aP < 0.5, bP < 0.01, Mann-Whitney U test. CCR, CC chemokine receptor; IFNγ, interferon-gamma; IL, interleukin.

Fagin et al. Arthritis Research & Therapy 2012 14:R73   doi:10.1186/ar3794

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