Table 2

Comparison of PET-CT outcome with MRI and conventional radiography of subpopulation scanned with [¹⁸F]FDG, [¹¹C](R)PK11195, and [¹⁸F]fluoride

Patient

Anatomic location

X-ray

PET-CT^a

MRI

Score^b

Level

Lesion

[¹⁸F]FDG

[¹⁸F]Fluoride

T1+Gd

STIR

Cervical

0

2 p

FA

-

-

-

3 p

FA

7 p

7 p

7 p

8 a

SC

8a

8 a

8 a

8 a

9 a

SC

9 a

9 a

9 a

1

Spine

Thoracic

0

10 a

SC

10 a

10 a

10 a

11 a

SC

11 a

11 a

11 a

12 a

SC

Lumbar

0

4 p

FA

-

4 p

-

-

5 p

FA

5 p

Sacroiliac joints

2

2

R

L

SC

SC

Cervical

0

-

-

-

-

6 a

6 a

7 a

7 a

1 p

1 p

1 p

6 p

8 p

Thoracic

0

9 a/p

SQ

9 p

Spine

10 a/p

SQ

10a

10 p

2

11 a/p

SQ

11a

11 p

12 a/p

SQ

-

2 a

2 a

3 a

Lumbar

2

4 a

SQ

5 a

Sacroiliac joints

4

3

R

L

Ank

SC

-

-

R

L

Ank

sfmi

Ank

sfmi

Ank

sfmi

Ank

sfmi

Levels on positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI) scans are hotspots with increased signal. ^a[¹¹C](R)PK11195 is not presented, because all scans were negative. ^bX-ray according to modified Stoke Ankylosing Spondylitis Spinal Score (m-SASSS) (0 to 72). a, anterior; Ank, ankylosis; [¹¹C](R)PK11195, PK11195 [(R)-1-(2-chlorophenyl)-N-methyl-N(1-methyl-propyl)-3-soquinoline carboxamide]; FA, facet arthrosis; L, left; p, posterior; R, right; SC, sclerosis; sfmi, subchondral fatty marrow infiltration; SQ, squaring; STIR, short-tau inversion recovery; T1+Gd, gadolinium contrast uptake on T1 images.

Bruijnen et al. Arthritis Research & Therapy 2012 14:R71   doi:10.1186/ar3792