Figure 3.

Effects of the rs3825427 genotype in UBAC2 on luciferase activity in cultured HEK 293 cells. pGL3 luciferase reporter recombinant plasmids containing an UBAC2 promoter sequence with the risk allele T or wild-type G allele at SNP rs3825427 were transfected into HEK293 cells. Renilla luciferase plasmid pTK-SV40 was cotransfected with each construct as an internal control for normalization. The mean ± SD is given for each construct from three experiments. Statistical significance was taken when two-tailed P < 0.05 using SPSS17.0 independent sample t test.