Table 1

IL-22 production by activated synovial fluid (SF) and peripheral blood (PB) CD3⁺ T cells.

IL-22 concentration (pg/ml)

24 hr. Incubation

48 hr. Incubation

Unstimulated (Mean ± SEM)

CD3/CD28

Stimulated

(Mean ± SEM)

PMA/Ionomycin

Stimulated

(Mean ± SEM)

Unstimulated (Mean ± SEM)

PHA Stimulated (Mean ± SEM)

PsA

(n = 10)

SF-T cells

3.85 ± 0.51

14.57 ± 0.80*^$

18.92 ± 0.89**^#$

4.21 ± 0.5

95.55 ± 7.81***^#$

PB-T cells

3.65 ± 0.23

10.44 ± 0.66*

12.83 ± 0.79*

4.28 ± 0.44

48.13 ± 6.38***^$

RA

(n = 10)

SF-T cells

4.22 ± 0.31

14.32 ± 0.96*^$

18.91 ± 1.97**^#$

4.63 ± 0.37

81.63 ± 5.90***^#$

PB-T cells

4 ± 0.16

10.56 ± 0.48*

11.88 ± 0.18*

4.1 ± 0.26

53.08 ± 4.58***^$

OA

(n = 8)

SF-T cells

4.63 ± 0.57

8.61 ± 0.79

13.59 ± 0.81*

4.79 ± 0.12

39.06 ± 3.92***

PB-T cells

3.94 ± 0.22

6.88 ± 0.34

11.44 ± 0.78*

4.04 ± 0.18

32.78 ± 2.56***

* p < 0.05, **p < 0.01, compared to 24 hr unstimulated media; ***p < 0.001, compared to 48 hr unstimulated media, Wilcoxon matched pairs signed rank test. ^#p < 0.05, compared to PB-T cells; ^$p < 0.05, ^$$p < 0.01, compared to that of OA, Mann Whitney test.

Mitra et al. Arthritis Research & Therapy 2012 14:R65   doi:10.1186/ar3781