Table 2 |
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Estimated life span of protective and autoreactive humoral immunity during long-term B-cell depletiona |
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Individual data analysis |
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Pooled data analysisb |
Life span in yearsc |
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Median life span in years (Spearman's ρ)d |
Median (range) |
Spearman's ρ (range)d |
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|
Total IgG |
38.3 (0.89) |
35.5 (10.1 to ∞) |
0.75 (0.09 to 0.99) |
|
ACPA-IgG |
9.08 (0.89) |
10.1 (5.22 to ∞) |
0.83 (0.48 to 1.0) |
|
Measles-IgG |
∞ (0.66) |
∞ (15.9 to ∞) |
0.48 (0.01 to 0.92) |
|
Mumps-IgG |
∞ (0.90) |
∞ (24.0 to ∞) |
0.60 (0.04 to 0.84) |
|
Rubella-IgG |
75.5 (0.35) |
153 (9.03 to ∞) |
0.41 (0.04 to 0.93) |
|
Total IgM |
12.3 (0.96) |
10.6 (6.0 to 36.7) |
0.83 (0.38 to 1.0) |
|
ACPA-IgM |
11.7 (1.0) |
14.9 (5.71 to ∞) |
0.88 (0.07 to 0.99) |
|
RF-IgM |
4.78 (0.96) |
5.27 (4.35 to 7.20) |
0.94 (0.68 to 0.99) |
|
Total IgA |
33.5 (0.85) |
22.8 (8.47 to ∞) |
0.77 (0.26 to 0.95) |
|
ACPA-IgA |
9.48 (0.71) |
9.33 (6.15 to 48.4) |
0.88 (0.16 to 0.98) |
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aACPA = anticitrullinated peptide antibody; Ig = immunoglobulin; RF = rheumatoid factor. bLife span was estimated using the median data for all patients pooled together as depicted in Figure 3. cLife span was estimated for each individual patient, here summarised in the depicted medians (ranges). dSpearman's ρ data are correlation coefficients of the linear curves used to estimate the life span, which is explained in the Methods section. |
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Teng et al. Arthritis Research & Therapy 2012 14:R57 doi:10.1186/ar3770 |
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