Table 2

Estimated life span of protective and autoreactive humoral immunity during long-term B-cell depletiona

Individual data analysis


Pooled data analysisb

Life span in yearsc


Median life span in years (Spearman's ρ)d

Median (range)

Spearman's ρ (range)d


Total IgG

38.3 (0.89)

35.5 (10.1 to ∞)

0.75 (0.09 to 0.99)

ACPA-IgG

9.08 (0.89)

10.1 (5.22 to ∞)

0.83 (0.48 to 1.0)

Measles-IgG

∞ (0.66)

∞ (15.9 to ∞)

0.48 (0.01 to 0.92)

Mumps-IgG

∞ (0.90)

∞ (24.0 to ∞)

0.60 (0.04 to 0.84)

Rubella-IgG

75.5 (0.35)

153 (9.03 to ∞)

0.41 (0.04 to 0.93)

Total IgM

12.3 (0.96)

10.6 (6.0 to 36.7)

0.83 (0.38 to 1.0)

ACPA-IgM

11.7 (1.0)

14.9 (5.71 to ∞)

0.88 (0.07 to 0.99)

RF-IgM

4.78 (0.96)

5.27 (4.35 to 7.20)

0.94 (0.68 to 0.99)

Total IgA

33.5 (0.85)

22.8 (8.47 to ∞)

0.77 (0.26 to 0.95)

ACPA-IgA

9.48 (0.71)

9.33 (6.15 to 48.4)

0.88 (0.16 to 0.98)


aACPA = anticitrullinated peptide antibody; Ig = immunoglobulin; RF = rheumatoid factor. bLife span was estimated using the median data for all patients pooled together as depicted in Figure 3. cLife span was estimated for each individual patient, here summarised in the depicted medians (ranges). dSpearman's ρ data are correlation coefficients of the linear curves used to estimate the life span, which is explained in the Methods section.

Teng et al. Arthritis Research & Therapy 2012 14:R57   doi:10.1186/ar3770

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