Table 1 |
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Effects of long-term B-cell depletion on serum concentrations of total immunoglobulin secretion, autoantibodies and protective antibodiesa |
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|
Baseline |
6 months |
12 months |
18 months |
24 months |
|
|
|
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|
Total IgG (g/L) |
13.4 (5.4 to 16.5) |
10.5 (5.4 to 15.0)b |
10.4 (5.2 to 13.6) |
9.35 (5.2 to 13.6) |
9.15 (5.1 to 12.2)c |
|
ACPA-IgG (U/ml) |
423 (65.6 to 1116) |
349 (47.0 to 647)b |
243 (43.9 to 410) |
215 (57.2 to 361) |
199 (43.6 to 354)c |
|
Measles-IgG (U/ml) |
3.72 (2.43 to 4.71) |
3.81 (2.75 to 5.03) |
3.84 (2.53 to 5.03) |
3.58 (2.63 to 5.04) |
3.67 (2.81 to 4.94) |
|
Mumps-IgG (U/ml) |
3.16 (0.65 to 4.67) |
3.31 (0.53 to 4.77) |
3.31 (0.46 to 4.89) |
3.33 (0.64 to 4.78) |
3.62 (0.67 to 5.11) |
|
Rubella-IgG (U/ml) |
101 (50.2 to 303) |
100 (29.7 to 310) |
91.6 (20.5 to 333) |
103 (25.6 to 311) |
106 (26.9 to 301) |
|
Total IgM (g/L) |
1.7 (0.6 to 3.7) |
1.2 (0.3 to 2.1)b |
1.1 (0.2 to 2.2) |
1.0 (0.2 to 1.9) |
0.9 (0.2 to 2.0)c |
|
ACPA-IgM (U/ml) |
35.3 (23.4 to 101) |
24.4 (16.3 to 72.9)b |
21.4 (16.2 to 49.1) |
19.8 (14.4 to 37.0) |
20.0 (11.8 to 30.8)c |
|
RF-IgM (U/ml) |
76.0 (10.0 to 792) |
32 (8.0 to 385)b |
16 (5 to 555) |
13 (2.0 to 310) |
10 (1 to 208)c |
|
Total IgA (g/L) |
2.0 (1.2 to 5.5) |
1.7 (1.0 to 5.7)b |
1.8 (0.8 to 5.5) |
1.6 (0.8 to 4.3) |
1.55 (0.8 to 4.2)c |
|
ACPA-IgA (U/ml) |
20.7 (3.16 to 90.8) |
12.5 (5.22 to 87.4) |
9.79 (2.81 to 97.9) |
8.49 (3.69 to 60.3) |
8.50 (2.63 to 44.4)c |
|
|
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|
aACPA = anticitrullinated peptide antibody; Ig = immunoglobulin; RF = rheumatoid factor. Data are medians (ranges). bP < 0.05 (baseline versus 6 months). cP < 0.05 (6 months versus 24 months). |
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Teng et al. Arthritis Research & Therapy 2012 14:R57 doi:10.1186/ar3770 |
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