Table 1

Effects of long-term B-cell depletion on serum concentrations of total immunoglobulin secretion, autoantibodies and protective antibodiesa

Baseline

6 months

12 months

18 months

24 months


Total IgG (g/L)

13.4 (5.4 to 16.5)

10.5 (5.4 to 15.0)b

10.4 (5.2 to 13.6)

9.35 (5.2 to 13.6)

9.15 (5.1 to 12.2)c

ACPA-IgG (U/ml)

423 (65.6 to 1116)

349 (47.0 to 647)b

243 (43.9 to 410)

215 (57.2 to 361)

199 (43.6 to 354)c

Measles-IgG (U/ml)

3.72 (2.43 to 4.71)

3.81 (2.75 to 5.03)

3.84 (2.53 to 5.03)

3.58 (2.63 to 5.04)

3.67 (2.81 to 4.94)

Mumps-IgG (U/ml)

3.16 (0.65 to 4.67)

3.31 (0.53 to 4.77)

3.31 (0.46 to 4.89)

3.33 (0.64 to 4.78)

3.62 (0.67 to 5.11)

Rubella-IgG (U/ml)

101 (50.2 to 303)

100 (29.7 to 310)

91.6 (20.5 to 333)

103 (25.6 to 311)

106 (26.9 to 301)

Total IgM (g/L)

1.7 (0.6 to 3.7)

1.2 (0.3 to 2.1)b

1.1 (0.2 to 2.2)

1.0 (0.2 to 1.9)

0.9 (0.2 to 2.0)c

ACPA-IgM (U/ml)

35.3 (23.4 to 101)

24.4 (16.3 to 72.9)b

21.4 (16.2 to 49.1)

19.8 (14.4 to 37.0)

20.0 (11.8 to 30.8)c

RF-IgM (U/ml)

76.0 (10.0 to 792)

32 (8.0 to 385)b

16 (5 to 555)

13 (2.0 to 310)

10 (1 to 208)c

Total IgA (g/L)

2.0 (1.2 to 5.5)

1.7 (1.0 to 5.7)b

1.8 (0.8 to 5.5)

1.6 (0.8 to 4.3)

1.55 (0.8 to 4.2)c

ACPA-IgA (U/ml)

20.7 (3.16 to 90.8)

12.5 (5.22 to 87.4)

9.79 (2.81 to 97.9)

8.49 (3.69 to 60.3)

8.50 (2.63 to 44.4)c


aACPA = anticitrullinated peptide antibody; Ig = immunoglobulin; RF = rheumatoid factor. Data are medians (ranges). bP < 0.05 (baseline versus 6 months). cP < 0.05 (6 months versus 24 months).

Teng et al. Arthritis Research & Therapy 2012 14:R57   doi:10.1186/ar3770

Open Data