Table 1

Comparison of the success of antibodies to Ro52, Ro60, or La at inducing heart block in experimental models

Inducing factor

Species (strain)

Proportion of AVB, percentagea

AVB II/III, percentagea

Reference


Antibody transfer during gestation (specificity/antigen)

Ro52 and Ro60

Mouse (BALB/c)

47-100

0

Mazel, et al. [58] (1998)

Ro52/p200 (aa 200-239)

Rat (DA)

100

0

Ambrosi, et al. [59] (2012)

Ro52/N- or C-terminal

Rat (DA)

0

0

Immunization before gestation (specificity/antigen)

Ro52

Mouse (BALB/c)

25

10

Boutjdir, et al. [50] (1997)

Ro52

Mouse (BALB/c)

9

3.6

Miranda-Carus, et al. [53] (1998)

Ro52

Rabbit (New Zealand)

9

0.7 (20% pups born dead)

Xiao, et al. [56] (2001)

Ro52

Rat (DA)

45

0

Strandberg, et al. [55] (2010)

Rat (LEW)

10

0

Rat (PVG)

44

0

Ro52β

Mouse (BALB/c)

12

6

Miranda-Carus, et al. [53] (1998)

Ro52 (mouse)

Mouse (BALB/c)

9

0

Ro52 (aa 365-382)

Mouse (BALB/c)

0

0

Eftekhari, et al. [64] (2001)

Ro52 (aa 366-379)

Mouse (BALB/c)

0

0

Ro52/p200 (aa 200-239)

Rat (DA)

19

0

Salomonsson, et al. [45] (2005)

Ro60

Mouse (BALB/c)

19

0

Miranda-Carus, et al. [53] (1998)

Ro60b

Mouse (C3H/HEJ)

14

0

Suzuki, et al. [54] (2005)

La

Mouse (BALB/c)

7

0

Miranda-Carus, et al. [53] (1998)

Lab

Mouse (C3H/HEJ)

7

0

Suzuki, et al. [54] (2005)

Ro52, Ro60, and La

Mouse (FBV Cav1.2 non-transgenic littermates)

28

5.5

Karnabi, et al. [68] (2011)

Mouse (FBV Cav1.2 transgenic)

9

1.1

Mouse (C57BL/6 Cav1.3+/+)

18

3

Mouse (C57BL/6 Cav1.3-/-)

100

44


aAtrioventricular block (AVB) determined by neonatal electrocardiogram recording. bThe authors report the presence of anti-Ro or anti-La antibodies in the serum of mice immunized with La or Ro60, respectively. aa, amino acids; DA, Dark Agouti.

Ambrosi and Wahren-Herlenius Arthritis Research & Therapy 2012 14:208   doi:10.1186/ar3787