Table 5

Absolute and relative cytokine levels in healthy and OA serum, and in OA synovial fluid

Cytokine

Normal serum levels (pg/ml)a

OA serum levels (pg/ml)b

OA SF levels (pg/ml)c

Ratio of OA serum levels to normal serum levels

Ratio of OA SF levels to OA serum levels


IL-6

3.02

(2.7-4.4)

5.13

(4.4-5.8)

975.39

(454.0-2,689.5)

1.7

190.1


IL-1β

1.22

(1.0-1.3)

1.58

(1.4-1.8)

1.14

(1.0-1.7)

1.3

0.7


TNF

0.00

(0.0-0.0)

0.00

(0.0-0.0)

2.92

(0.0-13.3)

-

-


VEGF

20.53

(11.7-65.6)

78.22

(31.3-124.6)

496.31

(245.0-577.8)

3.8

6.3


MCP-1

3.59

(0.0-11.9)

18.53

(13.0-28.0)

107.67

(84.8-191.1)

5.2

5.8


IP-10

537.00

(376.1-750.4)

795.55

(684.7-1,029.7)

2,105.40

(923.2-4,913.3)

1.5

2.6


MIG

244.51

(173.5-374.6)

420.13

(308.4-568.6)

1,047.14

(389.8-1,925.3)

1.7

2.5


OA, osteoarthritis; SF, synovial fluid; IL, interleukin; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor; MCP-1, macrophage chemotactic protein 1; IP-10, interferon γ-induced protein 10; MIG, monokine-induced by interferon γ. aThe median (IQR); n = 34 healthy individuals. bThe median (IQR); n = 23 individuals with OA. cThe median (IQR); n = 10 individuals with OA.

Sohn et al. Arthritis Research & Therapy 2012 14:R7   doi:10.1186/ar3555

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