Table 1 |
|
|
Study schema for single-dose and multiple-dose escalation stagesa |
|
|
Stage dose and route |
Patients, n (active:placebo) |
|
|
|
|
SAD stage dose, route (cohort) |
|
|
0.3 IV (A) |
4:1 |
|
1.0 IV (B) |
4:1 |
|
1.0 SC (C) |
4:1 |
|
3.0 IV (D) |
4:1 |
|
3.0 SC (E) |
4:1 |
|
5.0 IV (F) |
4:1 |
|
MAD stage dose, route (cohort) |
|
|
1.0 SC (G) |
8:2 |
|
3.0 SC (H) |
16:4 |
|
5.0 IV (I) |
4:1 |
|
|
|
|
aIV = intravenously; MAD = multiple ascending doses; SAD = single ascending dose; SC = subcutaneously. |
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|
Emu et al. Arthritis Research & Therapy 2012 14:R6 doi:10.1186/ar3554 |
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