Table 1

Study schema for single-dose and multiple-dose escalation stagesa

Stage dose and route

Patients, n (active:placebo)


SAD stage dose, route (cohort)

0.3 IV (A)

4:1

1.0 IV (B)

4:1

1.0 SC (C)

4:1

3.0 IV (D)

4:1

3.0 SC (E)

4:1

5.0 IV (F)

4:1

MAD stage dose, route (cohort)

1.0 SC (G)

8:2

3.0 SC (H)

16:4

5.0 IV (I)

4:1


aIV = intravenously; MAD = multiple ascending doses; SAD = single ascending dose; SC = subcutaneously.

Emu et al. Arthritis Research & Therapy 2012 14:R6   doi:10.1186/ar3554

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