MKK7 ASO reduces histologic damage in K/BxN serum transfer arthritis. Hind paws were collected at Day 10 after treatment with MKK7 ASO and sectioned for histologic assessment as described. (A) Representative sections of the ankle joints stained with H&E (upper, ×100) and toludine blue (lower, ×100). (B) Histology scores in ankle joints. Values = Mean ± SE, n = 7 to 8 for each group, *P < 0.05 and **P < 0.01 vs. control ASO.
Lee et al. Arthritis Research & Therapy 2012 14:R38 doi:10.1186/ar3750