Table 3

Comparison of participants with and without ED

No erectile dysfunction (n = 23)

Erectile dysfunction (n = 105)

Odds ratio (95% confidence interval)


IIEF-5 score

23 (22 to 25)

11 (5 to 16)

P < 0.001*

Age (years)a

45 (35.1 to 51.8)

55.7 (47.1 to 62.9)

P < 0.001*

SSc duration by Raynaud's phenomenon (years)

7.2 (4.3 to 15.3)

7.0 (3.4 to 11.6)

P = 0.44

SSc duration by first non-Raynaud's symptom (years)

6.6 (4.3 to 11.8)

5.6 (2.8 to 9.8)

P = 0.41

Topoisomerase I (Scl70)-positive

47.6

45.1

0.98 (0.80 to 1.19)

ACA-positive

5.0

18.8

1.21 (1.02 to 1.44)*

U1RNP-positive

0

5.9

1.25 (1.12 to 1.39)*

RNA polymerase III-positive

0

3.5

1.20 (1.08 to 1.33)*

Diffuse SSc

50

65.9

1.13 (0.92 to 1.40)

Puffy hands

57.1

52.9

0.97 (0.80 to 1.16)

mRSS

7 (2 to 19)

14 (8 to 23)

P = 0.05*

mRSS > 20

15.8

26.8

1.13 (0.91 to 1.40)

C-reactive protein elevation

14.3

25.3

1.13 (0.93 to 1.37)

Raynaud's phenomenon

90.5

95.5

1.22 (0.69 to 2.17)

Digital ulcers

47.6

41.9

0.95 (0.79 to 1.16)

Synovitis

19.1

19.5

1.01 (0.80 to 1.27)

Joint contractures

19.1

33.3

1.14 (0.95 to 1.36)

Tendon friction rubs

4.8

10.3

1.13 (0.90 to 1.42)

Muscle weakness

9.5

20.7

1.15 (0.96 to 1.38)

Muscle atrophy

4.8

18.4

1.21 (1.03 to 1.42)*

Creatine kinase elevation

19.1

12.2

0.88 (0.62 to 1.25)

Oesophageal symptoms

57.1

59.1

1.02 (0.84 to 1.23)

Stomach symptoms

19.1

12.5

0.90 (0.65 to 1.23)

Intestinal symptoms

4.8

15.9

1.19 (0.99 to 1.41)

Lung fibrosis on chest X-ray or HRCT

42.9

56.9

1.13 (0.87 to 1.47)

Forced vital capacity (% predicted)

95 (87 to 107)

91 (78 to 192)

P = 0.52

Forced vital capacity < 80%

9.5

25.7

1.26 (1.01 to 1.56)*

DLCO (% predicted)

81 (73 to 91)

66 (53 to 82)

P = 0.08

DLCO < 80%

42.9

63.6

1.24 (0.95 to 1.61)

PAPsys (mmHg)

23.5 (0 to 28)

29 (22 to 37)

P = 0.04*

PAPsys > 40 mmHg

0

24.4

1.32 (1.17 to 1.50)*

Diastolic dysfunction

15.8

17.3

1.02 (0.79 to 1.33)

Pericardial effusion

5.6

4.4

0.95 (0.53 to 1.68)

Left ventricular ejection fraction < 60%

27.8

18.3

0.88 (0.65 to 1.20)

Renal crisis

0

4.6

1.25 (1.14 to 1.38)*

Proteinuria

19.1

6.0

0.68 (0.37 to 1.22)

EULAR SSc activity score

1.0 (0.5 to 2.0)

2.5 (1.0 to 3.5)

P = 0.02*

High SSc activity (score ≥ 3)

11.8

43.4

1.38 (1.09 to 1.75)*

Hypocomplementaemia

5.0

6.3

1.05 (0.72 to 1.52)


Data presented as median (interquartile range) or percentage unless indicated otherwise. DLCO, diffusion capacity of the lung for carbon monoxide; HRCT; IIEF-5, International Index of Erectile Function-5; mRSS; modified Rodnan skin score; PAPsys, systolic pulmonary arterial pressure; SSc, systemic sclerosis. aAge presented as mean + standard deviation (minimum to maximum). The star (*) denotes statistical significance

Foocharoen et al. Arthritis Research & Therapy 2012 14:R37   doi:10.1186/ar3748

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