Table 1

Sequences of synthetic fibronectin peptides

Peptide name

Peptides identified in RA SFa

Synthetic peptidea

Citrulline residues identified in RA1

Citrulline residues identified in RA2


FN-Cit241

DTRTSYXIGDTWSK, TSYXIGDTWSK

DTRTSYXIGDTWSZO

X

X

FN-Arg241

DTRTSYRIGDTWSZO

FN-Cit1035,1036

LTVGLTXXGQPR, AQITGYRLTVGLTXR

LTVGLTXXGQPRQYZO

X

Xb

FN-Arg1035,1036

LTVGLTRRGQPRQYZO

FN-Cit1162

DGQEXDAPIVNK

LRDGQEXDAPIVNZO

X

X

FN-Arg1162

LRDGQERDAPIVNZO

FN-Cit2356

RPGGEPSPEGTTGQSYNQYSQXYHQR

YNQYSQXYHQRTNZO

X

FN-Arg2356

YNQYSQRYHQRTNZO


a O, biotinylated lysine; X, citrulline; Z, aminohexanoic acid. b Only citrulline at position 1035 was identified

van Beers et al. Arthritis Research & Therapy 2012 14:R35   doi:10.1186/ar3744

Open Data