Table 1

Sequences of synthetic fibronectin peptides

Peptide name

Peptides identified in RA SF^a

Synthetic peptide^a

Citrulline residues identified in RA1

Citrulline residues identified in RA2

FN-Cit₂₄₁

DTRTSYXIGDTWSK, TSYXIGDTWSK

DTRTSYXIGDTWSZO

X

X

FN-Arg₂₄₁

DTRTSYRIGDTWSZO

FN-Cit_1035,1036

LTVGLTXXGQPR, AQITGYRLTVGLTXR

LTVGLTXXGQPRQYZO

X

X^b

FN-Arg_1035,1036

LTVGLTRRGQPRQYZO

FN-Cit₁₁₆₂

DGQEXDAPIVNK

LRDGQEXDAPIVNZO

X

X

FN-Arg₁₁₆₂

LRDGQERDAPIVNZO

FN-Cit₂₃₅₆

RPGGEPSPEGTTGQSYNQYSQXYHQR

YNQYSQXYHQRTNZO

X

FN-Arg₂₃₅₆

YNQYSQRYHQRTNZO

^a O, biotinylated lysine; X, citrulline; Z, aminohexanoic acid. ^b Only citrulline at position 1035 was identified

van Beers et al. Arthritis Research & Therapy 2012 14:R35   doi:10.1186/ar3744