Figure 6.

Anti-FN-Cit_1035,1036 antibodies are predominantly of the IgG isotype. Sera from a subset of anti-FN-Cit_1035,1036-positive early arthritis patients (n = 23) taken at baseline (t = 0) and after a median follow-up of seven years later (t = 7) were analyzed for different anti-FN-Cit_1035,1036 antibody isotypes in ELISA. A. IgG isotype reactivity at t = 0. B. IgG isotype reactivity at t = 7. C. IgM isotype reactivity at t = 0. D. IgM isotype reactivity at t = 7. E. IgA isotype reactivity at t = 0. F. IgA isotype reactivity at t = 7. G. Anti-FN-Cit_1035,1036 IgG reactivity at t = 0 and t = 7. The broken lines indicate the cut-off values determined by normal human control sera.