Open Access Research article

Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles

Joyce JBC van Beers1*, Annemiek Willemze2, Judith Stammen-Vogelzangs1, Jan W Drijfhout3, René EM Toes2 and Ger J M Pruijn1

Author Affiliations

1 Department of Biomolecular Chemistry, Institute for Molecules and Materials, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

2 Department of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

3 Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

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Arthritis Research & Therapy 2012, 14:R35  doi:10.1186/ar3744

Published: 17 February 2012

Additional files

Additional file 1:

Supplementary Table 1 and Supplementary Figures 1 to 3. Supplementary Table 1: Association of anti-citrullinated fibronectin antibodies and HLA-DRB1 alleles in anti-CCP2-positive early arthritis patients. Supplementary Figure 1: Overview of the handling of synovial fluid samples. Supplementary Figure 2: Fibronectin-derived peptides identified in the synovial fluid of RA patients. Supplementary Figure 3: Correlation between anti-CCP2 and anti-FN-Cit1035,1036 reactivities.

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