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Open Access Highly Accessed Research article

Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis

Natalie A Carter*, Elizabeth C Rosser and Claudia Mauri

Author Affiliations

Centre for Rheumatology Research, Division of Medicine, University College London, Rayne Building, 5 University Street, London, WC1E 6JF, UK

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Arthritis Research & Therapy 2012, 14:R32  doi:10.1186/ar3736

Published: 8 February 2012

Additional files

Additional file 1:

Supplemental Data 1. Data to demonstrate that B and T cell development and Teff functional responses were unaffected in IL-10-/- B cell animals.

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Additional file 2:

Supplemental Data 2. Data showing the percentage of FoxP3+ Tregs and CD4- derived IL-10, IFN╬│ and IL-17 on days 12, 35 and 45 post-immunization for CIA.

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Open Data