Table 1 |
||||||
|
Distribution of HLA-B*51 and HLA-B*52 allele groups in healthy controls and Takayasu's arteritis patientsa |
||||||
|
Characteristics |
n |
HLA-B*52+ (%) |
P |
OR (95% CI) |
HLA-B*51+ (%) |
P |
|
|
||||||
|
HC |
210 |
14 (6.7) |
52 (24.8) |
|||
|
Men |
97 |
6 (6.2) |
23 (23.7) |
|||
|
Women |
113 |
8 (7.1) |
29 (25.7) |
|||
|
TAK |
330 |
69 (20.9) |
0.000 |
3.7 (2.02 to 6.77) |
75 (22.7) |
0.64 |
|
Men |
42 |
7 (16.7) |
0.063 |
12 (28.6) |
0.53 |
|
|
Women |
288 |
62 (21.5) |
0.000 |
3.6 (1.66 to 7.79) |
63 (21.9) |
0.43 |
|
Age at onset |
||||||
|
< 40 years |
240 |
58 (24.2) |
0.024 |
0.43 (0.20 to 0.91) |
49 (20.4) |
0.11 |
|
≤ 40 years |
75 |
9 (12.0) |
22 (29.3) |
|||
|
Angiographic subtypeb |
||||||
|
Type I |
130 |
17 (13.1) |
0.005 |
0.43 (0.23 to 0.78) |
28 (21.5) |
0.78 |
|
Type Iia |
21 |
8 (38.1) |
6 (28.6) |
|||
|
Type Iib |
9 |
3 (33.3) |
2 (22.2) |
|||
|
Type III |
13 |
5 (38.5) |
3 (23.1) |
|||
|
Type IV |
15 |
3 (20.0) |
1 (6.7) |
|||
|
Type V |
142 |
34 (23.9) |
35 (24.6) |
|||
|
Surgery (all) |
||||||
|
Present |
66 |
9 (13.6) |
0.092 |
0.51 (0.24 to 1.09) |
13 (19.7) |
0.62 |
|
Not present |
246 |
58 (23.6) |
57 (23.2) |
|||
|
Surgery after IS treatment |
||||||
|
Present |
36 |
7 (19.4) |
1.0 |
9 (25) |
0.67 |
|
|
Not present |
273 |
59 (21.6) |
60 (22.0) |
|||
|
Refractory disease |
||||||
|
Refractory |
114 |
31 (27.4) |
0.084 |
1.68 (0.97 to 2.93) |
20 (17.5) |
0.12 |
|
Not refractory |
193 |
35 (18.1) |
49 (25.4) |
|||
|
|
||||||
|
aHC, healthy control; IS, immunosuppressive; TAK, Takayasu's arteritis. Subgroup analysis was performed between groups with or without known clinical features. bP vs other all other subtypes. |
||||||
|
Sahin et al. Arthritis Research & Therapy 2012 14:R27 doi:10.1186/ar3730 |
||||||
