Open Access Research article

Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey

Ziver Sahin1, Muge Bıcakcıgil2, Kenan Aksu3, Sevil Kamali4, Servet Akar5, Fatos Onen5, Omer Karadag6, Zeynep Ozbalkan7, Askin Ates7, Huseyin TE Ozer8, Vuslat Yilmaz1, Emire Seyahi9, Mehmet A Ozturk10, Ayse Cefle11, Veli Cobankara12, A Mesut Onat13, Ercan Tunc14, Nursen Düzgün15, Sibel Z Aydin16, Neslihan Yilmaz16, İzzet Fresko9, Yasar Karaaslan7, Sedat Kiraz6, Nurullah Akkoc5, Murat Inanc4, Gokhan Keser3, F Aytul Uyar1, Haner Direskeneli16*, Güher Saruhan-Direskeneli1 and the Turkish Takayasu Study Group

Author affiliations

1 Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Capa 34093, Istanbul, Turkey

2 Department of Rheumatology, Yeditepe University, Faculty of Medicine, Ankara Cad No:102/104, Kozyatagı 34752, Istanbul, Turkey

3 Department of Rheumatology, Ege University, Faculty of Medicine, Ankara Asfalti Uzeri, Bornova 35100, Izmir, Turkey

4 Department of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Capa 34093, Istanbul, Turkey

5 Department of Rheumatology, Dokuz Eylül University, Faculty of Medicine, Dokuz Eylul Universitesi Saglık Yerleskesi, Inciraltı 35340, Izmir, Turkey

6 Department of Rheumatology, Hacettepe University, Faculty of Medicine, Sihhiye 06100, Ankara, Turkey

7 Department of Rheumatology, Ankara Numune Training and Research Hospital, Talatpasa Bulvarı, No:5, Altındag 06100, Ankara, Turkey

8 Department of Rheumatology, Cukurova University, Faculty of Medicine, Balcalı, Sarıcam 01330, Adana, Turkey

9 Department of Rheumatology, Istanbul University, Cerrahpaşa Faculty of Medicine, Kocamustafapaşa Cad. No: 124, Cerrahpaşa 34098, Istanbul, Turkey

10 Department of Rheumatology, Gazi University, Faculty of Medicine, Besevler 06500, Ankara, Turkey

11 Department of Rheumatology, Kocaeli University, Faculty of Medicine, Eski İstanbul Yolu, Umuttepe Yerleşkesi 41380, Kocaeli, Turkey

12 Department of Rheumatology, Pamukkale University Faculty of Medicine, Üniversite Caddesi Kınıklı Kampüsü 20020, Denizli, Turkey

13 Department of Rheumatology, Gaziantep University, Faculty of Medicine, Sahinbey Araştırma Hastanesi 27310, Gaziantep, Turkey

14 Department of Rheumatology, Suleyman Demirel University, Faculty of Medicine, Doğu Kampüsü Morfoloji Binası Kat:2 32260, Isparta, Turkey

15 Department of Rheumatology, Ankara University, Faculty of Medicine, Morfoloji Yerleşkesi, Sıhhıye 06100, Ankara, Turkey

16 Department of Rheumatology, Marmara University, Faculty of Medicine, Mimar Sinan Caddesi, No: 41, Pendik 34890, Istanbul, Turkey

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Citation and License

Arthritis Research & Therapy 2012, 14:R27  doi:10.1186/ar3730

Published: 6 February 2012

Abstract

Introduction

HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B*52 as susceptibility and severity factors.

Methods

TAK patients (n = 330) followed at a total of 15 centers were included in the study. The mean age of the patients was 37.8 years, and 86% were women. DNA samples from the patients and healthy controls (HC; n = 210) were isolated, and the presence of HLA-B*51 or HLA-B*52 was screened for by using PCR with sequence-specific primers.

Results

We found a significant association of HLA-B*52 with TAK (20.9% vs HC = 6.7%, P = 0.000, OR = 3.7, 95% CI = 2.02 to 6.77). The distribution of HLA-B*51 did not differ between TAK patients and HCs (22.7% vs 24.8%, OR = 0.9, 95% CI = 0.60 to 1.34). The presence of HLA-B*52 decreased in late-onset patients (> 40 years of age; 12.0%, P = 0.024, OR = 0.43, 95% CI = 0.20 to 0.91). Patients with angiographic type I disease with limited aortic involvement also had a lower presence of HLA-B*52 compared to those with all other disease subtypes (13.1% vs 26%, P = 0.005, OR = 0.43, 95% CI = 0.23 to 0.78).

Conclusions

In this study, the previously reported association of TAK with HLA-B*52 in other populations was confirmed in patients from Turkey. The functional relevance of HLA-B*52 in TAK pathogenesis needs to be explored further.