Additional file 1.

Coronal section of the OA rat knee stained with Picrosirius Red (5× magnification). Subchondral cysts (SBC) within the medial tibial plateau stained positively for the presence of collagen within the lesion itself (black arrows). This confirms that the composition of the focal areas of bone loss, observed in co-registered micro-CT and MRI images, have a different composition than the normal marrow (yellow arrow). SBC appeared adjacent to the joint surface and were characteristically found in the region of the knee with the most severe cartilage degradation.

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McErlain et al. Arthritis Research & Therapy 2012 14:R26   doi:10.1186/ar3727