Table 3

Multivariable analysis of the correlation between selected immune response profiles and radiographic joint damage.*

Principal Component and Model

Sharp-van der Heijde Radiographic Score


Total

Erosions

JSN


R

P

r

P

r

P


CMV/EBV-1

Unadjusted

0.31

0.018

0.33

0.011

0.17

0.18

Adjusted

0.39

0.006

0.39

0.006

0.19

0.20

+ CMV IgG

0.38

0.009

0.43

0.003

0.08

0.61

PMA/ionomycin-2

Unadjusted

0.24

0.07

0.27

0.042

0.15

0.27

Adjusted

0.01

0.93

0.09

0.53

-0.12

0.44

+ CMV IgG

0.01

0.99

0.09

0.56

-0.14

0.36


*Correlations between stimulus-cytokine principal components scores and the Sharp-van der Heijde total, erosion, and joint space narrowing (JSN) scores were selected for presentation here based on at least one statistically significant unadjusted result. Values are Spearman correlation coefficients and associated P-values. Adjusted for age, sex, disease duration, RF or ACPA positivity, HAQ disability index, DAS28, methotrexate use, biologic response modifier use, and prednisone use. Adjusted for all covariates with the addition of CMV IgG. CMV/EBV-1, first principal component for cytomegalovirus/Epstein-Barr virus; IgG, immunoglobulin G; JSN, joint space narrowing; PMA/ionomycin-2, second principal component for phorbol myristate acetate with ionomycin

Davis et al. Arthritis Research & Therapy 2012 14:R24   doi:10.1186/ar3706

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