Dexamethasone (DXM) decreases the expression of citrullinated proteins and PAD4 expression in a rheumatoid arthritis (RA) synovial explant. Brown diaminobenzidine immunoperoxidase staining shows citrullinated proteins as detected with F95 antibody, PAD2 as detected with ROI001 antibody, and PAD4 as detected with SN823 antibody. Original magnification, ×250.
Makrygiannakis et al. Arthritis Research & Therapy 2012 14:R20 doi:10.1186/ar3702