Table 2

Articular cartilage histologic evaluation criteria

Criteria for histologic evaluation of articular cartilage


Safranin O-fast green staining

0

No loss

1

Mild loss

2

Moderate loss

3

Severe loss

Chondrocyte loss

0

No decrease in cells

1

Minimal decrease in cells

2

Moderate decrease in cells

3

Marked decrease in cells

4

Very extensive decrease in cells

Structure

0

Normal

1

Surface irregularities

2

One to three superficial clefts

3

More than three superficial clefts

4

One to three clefts extending into the middle zone

5

More than three clefts extending into the middle zone

6

One to three clefts extending into the deep zone

7

More than three clefts extending into the deep zone

8

Clefts extending to calcified cartilage

Chondrocyte clones

0

Normal

1

Minimal (≤4)

2

Moderate (> 4 but ≤8)

3

Marked (> 8)

Tidemark integrity

0

Intact

1

Crossed by blood vessels

Tidemark duplication

0

No change

1

Duplication of tidemark

2

No visible tidemark remaining

Subchondral bone thickness

0

Subchondral bone thickness less than thickness of cartilage

1

Subchondral bone thickness equal to thickness of cartilage

2

Subchondral bone thickness more than thickness of cartilage


Rowas et al. Arthritis Research & Therapy 2012 14:R17   doi:10.1186/ar3696

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