Table 2 |
|
|
Articular cartilage histologic evaluation criteria |
|
|
Criteria for histologic evaluation of articular cartilage |
|
|
|
|
|
Safranin O-fast green staining |
|
|
0 |
No loss |
|
1 |
Mild loss |
|
2 |
Moderate loss |
|
3 |
Severe loss |
|
Chondrocyte loss |
|
|
0 |
No decrease in cells |
|
1 |
Minimal decrease in cells |
|
2 |
Moderate decrease in cells |
|
3 |
Marked decrease in cells |
|
4 |
Very extensive decrease in cells |
|
Structure |
|
|
0 |
Normal |
|
1 |
Surface irregularities |
|
2 |
One to three superficial clefts |
|
3 |
More than three superficial clefts |
|
4 |
One to three clefts extending into the middle zone |
|
5 |
More than three clefts extending into the middle zone |
|
6 |
One to three clefts extending into the deep zone |
|
7 |
More than three clefts extending into the deep zone |
|
8 |
Clefts extending to calcified cartilage |
|
Chondrocyte clones |
|
|
0 |
Normal |
|
1 |
Minimal (≤4) |
|
2 |
Moderate (> 4 but ≤8) |
|
3 |
Marked (> 8) |
|
Tidemark integrity |
|
|
0 |
Intact |
|
1 |
Crossed by blood vessels |
|
Tidemark duplication |
|
|
0 |
No change |
|
1 |
Duplication of tidemark |
|
2 |
No visible tidemark remaining |
|
Subchondral bone thickness |
|
|
0 |
Subchondral bone thickness less than thickness of cartilage |
|
1 |
Subchondral bone thickness equal to thickness of cartilage |
|
2 |
Subchondral bone thickness more than thickness of cartilage |
|
|
|
|
Rowas et al. Arthritis Research & Therapy 2012 14:R17 doi:10.1186/ar3696 |
|
