Table 7 |
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Genes linked to the cell cycle that are significantly down-regulated |
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Symbol |
Name |
Function |
|
|
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Cyclins and cyclin kinases |
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|
Ccna2 |
Cyclin a2 |
|
|
Ccnb1 |
Cyclin b1 |
|
|
Ccnb2 |
Cyclin b2 |
|
|
Ccnd3 |
Cyclin d3 |
|
|
Ccne1 |
Cyclin e1 |
|
|
Ccne2 |
Cyclin e2 |
|
|
Cdk1 |
Cyclin dependent kinase 1 |
|
|
Cdk2 |
Cyclin dependent kinase 2 |
|
|
Checkpoint regulators |
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|
Bub1 |
budding uninhibited by benzimidazoles 1 |
Kinase in spindle checkpoint function |
|
Bub1b |
budding uninhibited by benzimidazoles 1b |
Kinase in spindle checkpoint function |
|
Chek1 |
CHK1 checkpoint homolog |
Checkpoint regulator of cell cycle |
|
Chek2 |
CHK2 checkpoint homolog |
Checkpoint regulator of cell cycle |
|
Mad2l1 |
mitotic arrest deficient, homolog-like 1 |
Mitotic spindle checkpoint |
|
Minichromosome complex |
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|
Mcm2 |
minichromosome maintenance deficient 2 mitotin |
Regulator of cell cycle |
|
Mcm4 |
minichromosome maintenance deficient 4 |
Regulator of cell cycle |
|
Mcm5 |
minichromosome maintenance deficient 5 |
Regulator of cell cycle |
|
Mcm6 |
minichromosome maintenance deficient 6 |
Regulator of cell cycle |
|
Mcm7 |
minichromosome maintenance deficient 7 |
Regulator of cell cycle |
|
Transcription factors |
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|
E2F2 |
E2F transcription factor 2 |
Regulator of cell cycle |
|
Tpdp1 |
Transcription factor DP1 |
Partner of E2F transcription factors |
|
Tfdp2 |
Transcription factor DP1 |
Partner of E2F transcription factors |
|
Ttk |
Ttk protein kinase |
Mitosis associated kinase |
|
Other cell cycle regulators |
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|
Cdc6 |
cell division cycle 6 homolog |
Regulator of cell cycle |
|
Cdc20 |
cell division cycle 20 homolog |
Regulator of cell cycle |
|
Cdc25a |
cell division cycle 25a homolog |
Regulator of cell cycle |
|
Cdc25b |
cell division cycle 25b homolog |
Regulator of cell cycle |
|
Cdc45 |
cell division cycle 45 homolog |
Regulator of cell cycle |
|
Dbf4 |
DBF4 homolog (S. cerevisiae) |
Activator of S-phase kinase |
|
Espl1 |
extra spindle poles-like 1 |
Cleavage of sister chromatids |
|
Fzr1 |
fizzy/cell division cycle 20 related 1 |
Activation of the anaphase promoting complex during mitosis |
|
GADD45A |
Growth arrest and DNA damage inducible gene 45a |
Regulator of DNA repair and inhibitor of the S phase |
|
Orc1 |
origin recognition complex, subunit 1 |
Initiation of DNA replication |
|
Orc6 |
origin recognition complex, subunit 6 |
Initiation of DNA replication |
|
Plk1 |
Polo-like kinase 1 |
Promoter of mitosis |
|
Pcna |
proliferating cell nuclear antigen |
Cofactor of DNA polymerase delta |
|
Rb1 |
Retinoblastoma 1 |
Regulator of the cell cycle |
|
Rbl1 |
Retinoblastoma like 1 |
Regulator of the cell cycle |
|
|
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Lodewyckx et al. Arthritis Research & Therapy 2012 14:R16 doi:10.1186/ar3695 |
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