Table 7

Genes linked to the cell cycle that are significantly down-regulated

Symbol

Name

Function


    Cyclins and cyclin kinases

Ccna2

Cyclin a2

Ccnb1

Cyclin b1

Ccnb2

Cyclin b2

Ccnd3

Cyclin d3

Ccne1

Cyclin e1

Ccne2

Cyclin e2

Cdk1

Cyclin dependent kinase 1

Cdk2

Cyclin dependent kinase 2

    Checkpoint regulators

Bub1

budding uninhibited by benzimidazoles 1

Kinase in spindle checkpoint function

Bub1b

budding uninhibited by benzimidazoles 1b

Kinase in spindle checkpoint function

Chek1

CHK1 checkpoint homolog

Checkpoint regulator of cell cycle

Chek2

CHK2 checkpoint homolog

Checkpoint regulator of cell cycle

Mad2l1

mitotic arrest deficient, homolog-like 1

Mitotic spindle checkpoint

    Minichromosome complex

Mcm2

minichromosome maintenance deficient 2 mitotin

Regulator of cell cycle

Mcm4

minichromosome maintenance deficient 4

Regulator of cell cycle

Mcm5

minichromosome maintenance deficient 5

Regulator of cell cycle

Mcm6

minichromosome maintenance deficient 6

Regulator of cell cycle

Mcm7

minichromosome maintenance deficient 7

Regulator of cell cycle

    Transcription factors

E2F2

E2F transcription factor 2

Regulator of cell cycle

Tpdp1

Transcription factor DP1

Partner of E2F transcription factors

Tfdp2

Transcription factor DP1

Partner of E2F transcription factors

Ttk

Ttk protein kinase

Mitosis associated kinase

    Other cell cycle regulators

Cdc6

cell division cycle 6 homolog

Regulator of cell cycle

Cdc20

cell division cycle 20 homolog

Regulator of cell cycle

Cdc25a

cell division cycle 25a homolog

Regulator of cell cycle

Cdc25b

cell division cycle 25b homolog

Regulator of cell cycle

Cdc45

cell division cycle 45 homolog

Regulator of cell cycle

Dbf4

DBF4 homolog (S. cerevisiae)

Activator of S-phase kinase

Espl1

extra spindle poles-like 1

Cleavage of sister chromatids

Fzr1

fizzy/cell division cycle 20 related 1

Activation of the anaphase promoting complex during mitosis

GADD45A

Growth arrest and DNA damage inducible gene 45a

Regulator of DNA repair and inhibitor of the S phase

Orc1

origin recognition complex, subunit 1

Initiation of DNA replication

Orc6

origin recognition complex, subunit 6

Initiation of DNA replication

Plk1

Polo-like kinase 1

Promoter of mitosis

Pcna

proliferating cell nuclear antigen

Cofactor of DNA polymerase delta

Rb1

Retinoblastoma 1

Regulator of the cell cycle

Rbl1

Retinoblastoma like 1

Regulator of the cell cycle


Lodewyckx et al. Arthritis Research & Therapy 2012 14:R16   doi:10.1186/ar3695

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