Table 5

Genes related to ECM matrix and cell adhesion

Symbol

Name

Function


    Up-regulated genes in Frzb-/- mice

Collagens

Col3a1

Collagen alpha-1(III) chain

Fibril forming collagen - co-distributes with type I collagen

Col4a1

Collagen alpha-1(IV) chain

Basal lamina collagen

Col4a2

Collagen alpha-2(IV) chain

Basal lamina collagen

Col4a4

Collagen alpha-4(IV) chain

Basal lamina collagen

Col4a5

Collagen alpha-5(IV) chain

Basal lamina collagen

Col4a6

Collagen alpha-6(IV) chain

Basal lamina collagen

Col5a1

Collagen alpha-1(V) chain

Fibril forming collagen - co-distributes with type I collagen

Col5a3

Collagen alpha-3(V) chain

Fibril forming collagen - co-distributes with type I collagen Type V collagen

Col8a2

Collagen alpha-2(VIII) chain

Basal lamina collagen

Col12a1

Collagen alpha-1(XII) chain

FACIT collagen

Col14a1

Collagen alpha-1(XIV) chain

FACIT collagen

Col15a1

Collagen alpha-1(XVIII) chain

Antiangiogenic factor - pericellular matrix

Col16a1

Collagen alpha-1(XVI) chain

FACIT-collagen

Col18a1

Collagen alpha-1(XVIII) chain

antiangiogenic factor - pericellular matrix

Integrins

Itga8

Integrin alpha-8 light chain

RGD-binding integrin

Itgbl1

Integrin beta-like protein 1

Type B like integrin

Sdc2

syndecan 2

Heparan proteoglycan transmembrane protein

Growth factors and receptors

Egfr

epidermal growth factor receptor

Receptor for epidermal growth factor

Igf1

insulin-like growth factor 1

Growth factor stimulating ECM synthesis

Pdgfra

platelet derived growth factor receptor alpha chain

Receptor for platelet derived growth factors

Vegfc

vascular endothelial growth factor c

Pro-angiogenic factor - Flt4 ligand

Lims2

LIM and senescent cell antigen-like-containing domain protein 2

Focal adhesion molecule

Cytoskeleton molecules

Acta2

Actin, aortic smooth muscle

Parva

Alpha-parvin

Actin binding protein

Vcl

Vinculin

Actin binding protein

Extracellular matrix - integrin interacting molecules

Lamb1

laminin B1 subunit 1

Extracellular matrix glycoprotein

Lamg1

laminin, gamma 1

Extracellular matrix glycoprotein

Npnt

nephronectin

Ligand for integrin alpha 8/b1

Tnn

tenascin N

Extracellular matrix glycoprotein

Tnxb

tenascin XB

Extracellular matrix glycoprotein

Thbs2

thrombospondin 2

Extracellular matrix glycoprotein

Thbs4

thrombospondin 4

Extracellular matrix glycoprotein

    Down-regulated genes in Frzb-/- mice

Integrins

Itga4

Integrin alpha-4

Itgal

Integrin alpha-L

Itgam

Integrin alpha-M

Itgb2

Integrin beta-2

Itgb2l

Integrin beta-2-like protein

Focal adhesion molecule

Lims1

LIM and senescent cell antigen-like-containing domain protein 1

Focal adhesion molecule

Cytoskeleton molecules

Parvb

Beta-parvin

Actin binding protein

    Kinases

Map3k1

Mitogen-activated protein kinase kinase kinase 1

Mitogen activated kinase

Mapk13

Mitogen-activated protein kinase 13

Mitogen activated kinase

Grap2

GRB2-related adaptor protein 2

Adapator protein

Lck

Proto-oncogene tyrosine-protein kinase LCK

T cell specific kinase

Pik3cd

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Phosphoinositide 3-kinases

Pik3cg

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Phosphoinositide 3-kinases


Lodewyckx et al. Arthritis Research & Therapy 2012 14:R16   doi:10.1186/ar3695

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