Table 5 |
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Genes related to ECM matrix and cell adhesion |
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|
Symbol |
Name |
Function |
|
|
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Up-regulated genes in Frzb-/- mice |
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|
Collagens |
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|
Col3a1 |
Collagen alpha-1(III) chain |
Fibril forming collagen - co-distributes with type I collagen |
|
Col4a1 |
Collagen alpha-1(IV) chain |
Basal lamina collagen |
|
Col4a2 |
Collagen alpha-2(IV) chain |
Basal lamina collagen |
|
Col4a4 |
Collagen alpha-4(IV) chain |
Basal lamina collagen |
|
Col4a5 |
Collagen alpha-5(IV) chain |
Basal lamina collagen |
|
Col4a6 |
Collagen alpha-6(IV) chain |
Basal lamina collagen |
|
Col5a1 |
Collagen alpha-1(V) chain |
Fibril forming collagen - co-distributes with type I collagen |
|
Col5a3 |
Collagen alpha-3(V) chain |
Fibril forming collagen - co-distributes with type I collagen Type V collagen |
|
Col8a2 |
Collagen alpha-2(VIII) chain |
Basal lamina collagen |
|
Col12a1 |
Collagen alpha-1(XII) chain |
FACIT collagen |
|
Col14a1 |
Collagen alpha-1(XIV) chain |
FACIT collagen |
|
Col15a1 |
Collagen alpha-1(XVIII) chain |
Antiangiogenic factor - pericellular matrix |
|
Col16a1 |
Collagen alpha-1(XVI) chain |
FACIT-collagen |
|
Col18a1 |
Collagen alpha-1(XVIII) chain |
antiangiogenic factor - pericellular matrix |
|
Integrins |
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|
Itga8 |
Integrin alpha-8 light chain |
RGD-binding integrin |
|
Itgbl1 |
Integrin beta-like protein 1 |
Type B like integrin |
|
Sdc2 |
syndecan 2 |
Heparan proteoglycan transmembrane protein |
|
Growth factors and receptors |
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|
Egfr |
epidermal growth factor receptor |
Receptor for epidermal growth factor |
|
Igf1 |
insulin-like growth factor 1 |
Growth factor stimulating ECM synthesis |
|
Pdgfra |
platelet derived growth factor receptor alpha chain |
Receptor for platelet derived growth factors |
|
Vegfc |
vascular endothelial growth factor c |
Pro-angiogenic factor - Flt4 ligand |
|
Lims2 |
LIM and senescent cell antigen-like-containing domain protein 2 |
Focal adhesion molecule |
|
Cytoskeleton molecules |
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|
Acta2 |
Actin, aortic smooth muscle |
|
|
Parva |
Alpha-parvin |
Actin binding protein |
|
Vcl |
Vinculin |
Actin binding protein |
|
Extracellular matrix - integrin interacting molecules |
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|
Lamb1 |
laminin B1 subunit 1 |
Extracellular matrix glycoprotein |
|
Lamg1 |
laminin, gamma 1 |
Extracellular matrix glycoprotein |
|
Npnt |
nephronectin |
Ligand for integrin alpha 8/b1 |
|
Tnn |
tenascin N |
Extracellular matrix glycoprotein |
|
Tnxb |
tenascin XB |
Extracellular matrix glycoprotein |
|
Thbs2 |
thrombospondin 2 |
Extracellular matrix glycoprotein |
|
Thbs4 |
thrombospondin 4 |
Extracellular matrix glycoprotein |
|
Down-regulated genes in Frzb-/- mice |
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|
Integrins |
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|
Itga4 |
Integrin alpha-4 |
|
|
Itgal |
Integrin alpha-L |
|
|
Itgam |
Integrin alpha-M |
|
|
Itgb2 |
Integrin beta-2 |
|
|
Itgb2l |
Integrin beta-2-like protein |
|
|
Focal adhesion molecule |
||
|
Lims1 |
LIM and senescent cell antigen-like-containing domain protein 1 |
Focal adhesion molecule |
|
Cytoskeleton molecules |
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|
Parvb |
Beta-parvin |
Actin binding protein |
|
Kinases |
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|
Map3k1 |
Mitogen-activated protein kinase kinase kinase 1 |
Mitogen activated kinase |
|
Mapk13 |
Mitogen-activated protein kinase 13 |
Mitogen activated kinase |
|
Grap2 |
GRB2-related adaptor protein 2 |
Adapator protein |
|
Lck |
Proto-oncogene tyrosine-protein kinase LCK |
T cell specific kinase |
|
Pik3cd |
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform |
Phosphoinositide 3-kinases |
|
Pik3cg |
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
Phosphoinositide 3-kinases |
|
|
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|
Lodewyckx et al. Arthritis Research & Therapy 2012 14:R16 doi:10.1186/ar3695 |
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