Table 4

Genes linked to WNT signaling that are significantly up- or down-regulated

Symbol

Name

Function


    Up-regulated genes in Frzb-/- mice

WNT target genes

Acta2

actin, alpha 2, smooth muscle, aorta

Target gene

Rspo2

R-spondin 2 homolog (Xenopus laevis)

Target gene and stimulates WNT/β-catenin pathway

Sox17

SRY-box containing gene 17

Target gene

Tbl1x

transducin (beta)-like 1X-linked

Target gene and adaptor with the ubiquitin-conjugating/19S proteasome

Wisp2

WNT1 inducible signaling pathway protein 2

Target gene

WNT antagonists

Dkk2

dickkopf homolog 2 (Xenopus laevis)

Extracellular WNT antagonist

Dkk3

dickkopf homolog 3 (Xenopus laevis)

Extracellular WNT antagonist

Nkd1

naked cuticle 1 homolog (Drosophila)

Intracellular antagonist

Nkd2

naked cuticle 2 homolog (Drosophila)

Intracellular antagonist

Sfrp1

secreted frizzled-related protein 1

Extracellular WNT antagonist

Sfrp2

secreted frizzled-related protein 2

Extracellular WNT antagonist

Sfrp4

secreted frizzled-related protein 4

Extracellular WNT antagonist

WNT receptor

Fzd1

frizzled homolog 1 (Drosophila)

WNT receptor

Fzd2

frizzled homolog 2 (Drosophila)

WNT receptor

Fzd8

frizzled homolog 8 (Drosophila)

WNT receptor

Intracellular messenger molecules

Nfatc2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

Intracellular messenger in non-canonical calcium-dependent pathway

Nfatc4

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4

Intracellular messenger in non-canonical calcium-dependent pathway

Prickl2

prickle homolog 2 (Drosophila)

Intracellular messenger in non-canonical planar cell polarity pathway

Receptors of the TGFβ superfamily pathway

AcvrI

activin A receptor, type I

type I receptor for the TGFβ family

AcvrIc

activin A receptor, type IC

type I receptor for the TGFβ family

BmprIb

bone morphogenetic protein receptor, type 1B

type I receptor for the TGFβ family

Cell adhesion molecules

Cdh13

cadherin 13

Cell adhesion molecule

Dchs1

dachsous homolog 1 (Drosophila) - protocadherin 16

Cell adhesion molecule

Pcdh9

protocadherin 9

Cell adhesion molecule

Pcdh17

protocadherin 17

Cell adhesion molecule

Pcdh18

protocadherin 18

Cell adhesion molecule

Pcdh19

protocadherin 19

Cell adhesion molecule

    Down-regulated genes in Frzb-/- mice

WNT antagonists

Dkk1

dickkopf homolog 1 (Xenopus laevis)

Extracellular WNT antagonist

Btrc

beta-transducin repeat containing

Stimulates β-catenin ubiquitinilation

WNT receptor scaffolds

Arrb1

beta-arrestin 1

scaffold in intracellular WNT receptor complex

Arrb2

Beta-arrestin 2


Lodewyckx et al. Arthritis Research & Therapy 2012 14:R16   doi:10.1186/ar3695

Open Data