Table 4 |
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|
Genes linked to WNT signaling that are significantly up- or down-regulated |
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|
Symbol |
Name |
Function |
|
|
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|
Up-regulated genes in Frzb-/- mice |
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|
WNT target genes |
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|
Acta2 |
actin, alpha 2, smooth muscle, aorta |
Target gene |
|
Rspo2 |
R-spondin 2 homolog (Xenopus laevis) |
Target gene and stimulates WNT/β-catenin pathway |
|
Sox17 |
SRY-box containing gene 17 |
Target gene |
|
Tbl1x |
transducin (beta)-like 1X-linked |
Target gene and adaptor with the ubiquitin-conjugating/19S proteasome |
|
Wisp2 |
WNT1 inducible signaling pathway protein 2 |
Target gene |
|
WNT antagonists |
||
|
Dkk2 |
dickkopf homolog 2 (Xenopus laevis) |
Extracellular WNT antagonist |
|
Dkk3 |
dickkopf homolog 3 (Xenopus laevis) |
Extracellular WNT antagonist |
|
Nkd1 |
naked cuticle 1 homolog (Drosophila) |
Intracellular antagonist |
|
Nkd2 |
naked cuticle 2 homolog (Drosophila) |
Intracellular antagonist |
|
Sfrp1 |
secreted frizzled-related protein 1 |
Extracellular WNT antagonist |
|
Sfrp2 |
secreted frizzled-related protein 2 |
Extracellular WNT antagonist |
|
Sfrp4 |
secreted frizzled-related protein 4 |
Extracellular WNT antagonist |
|
WNT receptor |
||
|
Fzd1 |
frizzled homolog 1 (Drosophila) |
WNT receptor |
|
Fzd2 |
frizzled homolog 2 (Drosophila) |
WNT receptor |
|
Fzd8 |
frizzled homolog 8 (Drosophila) |
WNT receptor |
|
Intracellular messenger molecules |
||
|
Nfatc2 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 |
Intracellular messenger in non-canonical calcium-dependent pathway |
|
Nfatc4 |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
Intracellular messenger in non-canonical calcium-dependent pathway |
|
Prickl2 |
prickle homolog 2 (Drosophila) |
Intracellular messenger in non-canonical planar cell polarity pathway |
|
Receptors of the TGFβ superfamily pathway |
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|
AcvrI |
activin A receptor, type I |
type I receptor for the TGFβ family |
|
AcvrIc |
activin A receptor, type IC |
type I receptor for the TGFβ family |
|
BmprIb |
bone morphogenetic protein receptor, type 1B |
type I receptor for the TGFβ family |
|
Cell adhesion molecules |
||
|
Cdh13 |
cadherin 13 |
Cell adhesion molecule |
|
Dchs1 |
dachsous homolog 1 (Drosophila) - protocadherin 16 |
Cell adhesion molecule |
|
Pcdh9 |
protocadherin 9 |
Cell adhesion molecule |
|
Pcdh17 |
protocadherin 17 |
Cell adhesion molecule |
|
Pcdh18 |
protocadherin 18 |
Cell adhesion molecule |
|
Pcdh19 |
protocadherin 19 |
Cell adhesion molecule |
|
Down-regulated genes in Frzb-/- mice |
||
|
WNT antagonists |
||
|
Dkk1 |
dickkopf homolog 1 (Xenopus laevis) |
Extracellular WNT antagonist |
|
Btrc |
beta-transducin repeat containing |
Stimulates β-catenin ubiquitinilation |
|
WNT receptor scaffolds |
||
|
Arrb1 |
beta-arrestin 1 |
scaffold in intracellular WNT receptor complex |
|
Arrb2 |
Beta-arrestin 2 |
|
|
|
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|
Lodewyckx et al. Arthritis Research & Therapy 2012 14:R16 doi:10.1186/ar3695 |
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