Table 3

Multivariable adjusted hazard ratio for each study outcome by gout status

Hazard Ratio (95% Confidence Interval)

All study participants


Gout status

No gout

Treated gout

Untreated gout

N = 3,987

N = 129

N = 89

Mean sUA (SD)

6.06 (1.33)

7.18 (1.80)

7.00 (1.66)

All-cause death

1.00

0.84 (0.47, 1.50)

1.73a (1.03, 2.91)

CHD mortality

1.00

0.82 (0.43, 1.54)

2.00b (1.18, 3.36)

Coronary incidence

1.00

0.86 (0.58, 1.34)

1.67a (1.07, 2.62)

Stroke

1.00

2.11 (0.74, 6.03)

0.83 (0.11, 6.04)


aP < 0.05 for comparison of untreated gout group to no gout group; bP < 0.01 for comparison of untreated gout group to no-gout group. The covariates adjusted for in this regression included: age, gender, blood pressure/hypertension, smoking, diabetes status, physical activity measure, hyperlipidemia, hypertriglyceridemia, renal function, and other non-steroidal anti-inflammatory drug use. Gout medications accounted for in this study were allopurinol, probenecid, and colchicine. CHD, coronary heart disease; sUA, serum urate.

Krishnan et al. Arthritis Research & Therapy 2012 14:R10   doi:10.1186/ar3684

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