Table 2

Multivariable adjusted hazard ratio for each of the study outcomes stratified by quartile of serum uric acid concentration

Hazard ratio (95% CI)


Quartile 1

Quartile 2

Quartile 3

Quartile 4


Outcome

N = 1,090

N = 1,080

N = 1,092

N = 1,090

All-cause death

1.00

0.96

(0.72, 1.29)

1.15

(0.87, 1.54)

1.88a

(1.45, 2.46)

CHD mortality

1.00

0.97

(0.71, 1.33)

1.17

(0.86, 1.60)

1.99a

(1.49, 2.66)

Coronary incidence

1.00

0.91

(0.72, 1.15)

0.96

(0.76, 1.21)

1.36b

(1.08, 1.69)

Stroke

1.00

0.65

(0.32, 1.34)

0.59

(0.27, 1.29)

1.31

(0.69, 2.49)


aP < 0.001 in comparison to the first quartile; bP < 0.01. in comparison to first quartile; cTrend test performed using serum urate as a continuous variable. The covariates adjusted for in this regression included: age, gender, African-American ethnicity, body mass index, blood pressure/hypertension, smoking, diabetes status, physical activity measure, hyperlipidemia, hypertriglyceridemia, renal function, and other non-steroidal anti-inflammatory drug use.

CHD, coronary heart disease; CI, confidence interval; N, number.

Krishnan et al. Arthritis Research & Therapy 2012 14:R10   doi:10.1186/ar3684

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