Cumulative incidence of study endpoints according to baseline sUA concentration for patients receiving aspirin, placebo group, and all study participants: follow-up analysis of 4,352 participants in the AMIS Study. Aspirin group: quartile 1-2.5 to 4.5 mg/dL for men, 1.4 to 5.25 mg/dL for women; quartile 2-4.53 to 5.37 mg/dL for men, 5.27 to 6.03 mg/dL for women; quartile 3-5.38 to 6.45 mg/dL for men, 6.05 to 7.0 mg/dL for women; quartile 4-6.47 to 10.45 mg/dL for men, 7.02 to 12.52 mg/dL for women. Placebo group: quartile 1-2.38 to 4.48 mg/dL for men, 1.83 to 5.28 mg/dL for women; quartile 2-4.5 to 5.42 mg/dL for men, 5.3 to 6.03 mg/dL for women; quartile 3-5.47 to 6.48 mg/dL for men, 6.05 to 6.97 mg/dL for women; quartile 4-6.52 to 11.05 mg/dL for men, 6.98 to 12.12 mg/dL for women. For all outcomes except stroke, the difference in incidence between the first and fourth quartiles and a linear trend test were statistically significant (P < 0.05). AMIS, Aspirin Myocardial Infarction Study; CHD, Coronary Heart Disease, sUA, serum urate.
Krishnan et al. Arthritis Research & Therapy 2012 14:R10 doi:10.1186/ar3684