Pre-disease pregnancy complications and systemic sclerosis: pathogenic or pre-clinical?
Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Arthritis Research & Therapy 2012, 14:102 doi:10.1186/ar3686
See related research by Van Wyk et al., http://arthritis-research.com/content/13/6/R183Published: 6 February 2012
The fetal microchimerism theory for the pathogenesis of systemic sclerosis (SSc) has compelling biologic support, including the female predominance of the disease, the mean age of onset after childbearing years, similarities between diffuse cutaneous SSc and graft-versus-host disease, as well as the detection of microchimeric cells in peripheral blood and skin of SSc patients. The previous issue of Arthritis Research and Therapy presents findings of a positive association between pregnancy complications and future diagnosis of SSc in parous women. Before interpreting the results of this epidemiologic study as support for fetal microchimerism, however, other theories for the observed associations must be considered.