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Volume 14 Issue 1

Comment

Editorial   Free Highly Accessed

Autoimmunity induced by human cytomegalovirus in patients with systemic lupus erythematosus

Cecilia Söderberg-Nauclér Arthritis Research & Therapy 2012, 14:101 (23 January 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free

Pre-disease pregnancy complications and systemic sclerosis: pathogenic or pre-clinical?

Eliza Chakravarty Arthritis Research & Therapy 2012, 14:102 (6 February 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Autonomic dysfunction in women with fibromyalgia

J Derek Kingsley Arthritis Research & Therapy 2012, 14:103 (20 February 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Abatacept versus other biologics in methotrexate inadequate responders with rheumatoid arthritis: you like tomato and I like tomahto... let's call the whole thing off

Yusuf Yazici Arthritis Research & Therapy 2012, 14:104 (21 February 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

How does BAFF activate B cells in patients with autoimmune diseases?

Xavier Mariette Arthritis Research & Therapy 2012, 14:106 (24 February 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free

The BRIC-GARN Meeting 2011: of mice and men

David S Pisetsky Arthritis Research & Therapy 2012, 14:107 (24 February 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Inhibiting citrullination in rheumatoid arthritis: taking fuel from the fire

Benjamin AC Fisher, Patrick J Venables Arthritis Research & Therapy 2012, 14:108 (29 February 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free Highly Accessed

Clinical examination or whole-body magnetic resonance imaging: the Holy Grail of spondyloarthritis imaging

Winston J Rennie Arthritis Research & Therapy 2012, 14:110 (29 February 2012)

Abstract | Full text | PDF | PubMed

Editorial   Free

Role of environmental factors in autoantibody production - importance of a detailed analysis in a small cohort

Minoru Satoh, Angela Ceribelli, Edward KL Chan Arthritis Research & Therapy 2012, 14:109 (29 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Review

Review   Free Highly Accessed

Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?

Yves Henrotin, Ali Mobasheri, Marc Marty Arthritis Research & Therapy 2012, 14:201 (30 January 2012)

Abstract | Full text | PDF | PubMed

Review   Free Highly Accessed

Therapy of lupus nephritis: lessons learned from clinical research and daily care of patients

Frédéric A Houssiau Arthritis Research & Therapy 2012, 14:202 (31 January 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology

Review   Free

Endothelial progenitor cells: a new player in lupus?

Sahena Haque, M Yvonne Alexander, Ian N Bruce Arthritis Research & Therapy 2012, 14:203 (20 February 2012)

Abstract | Full text | PDF | PubMed

Review   Free

Contributions of mass spectrometry-based proteomics to defining cellular mechanisms and diagnostic markers for systemic lupus erythematosus

Erik A Korte, Patrick M Gaffney, David W Powell Arthritis Research & Therapy 2012, 14:204 (20 February 2012)

Abstract | Full text | PDF | PubMed

Review   Free

Taking responsibility for the early assessment and treatment of patients with musculoskeletal pain: a review and critical analysis

Nadine E Foster, Jan Hartvigsen, Peter R Croft Arthritis Research & Therapy 2012, 14:205 (29 February 2012)

Abstract | Full text | PDF | PubMed

Research

Research article   Open Access

Tumor necrosis factor α release in peripheral blood mononuclear cells of cutaneous lupus and dermatomyositis patients

Adam S Nabatian, Muhammad M Bashir, Maria Wysocka, Meena Sharma, Victoria P Werth Arthritis Research & Therapy 2012, 14:R1 (4 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

International cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis

Katja Lakota, Gerhard G Thallinger, Snezna Sodin-Semrl, Blaz Rozman, Ales Ambrozic, Matija Tomsic, Sonja Praprotnik, Sasa Cucnik, Katjusa Mrak-Poljsak, Angela Ceribelli, Ilaria Cavazzana, Franco Franceschini, Jiri Vencovsky, Laszlo Czirják, Cecilia Varjú, Gunther Steiner, Martin Aringer, Bojana Stamenkovic, Oliver Distler, Marco Matucci-Cerinic, Tanja Kveder Arthritis Research & Therapy 2012, 14:R2 (6 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Anterior chest wall inflammation by whole-body magnetic resonance imaging in patients with spondyloarthritis: lack of association between clinical and imaging findings in a cross-sectional study

Ulrich Weber, Robert GW Lambert, Kaspar Rufibach, Walter P Maksymowych, Juerg Hodler, Anna Zejden, Stefan Duewell, Rudolf O Kissling, Paul L Filipow, Anne G Jurik Arthritis Research & Therapy 2012, 14:R3 (6 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

No association was found between clinical and imaging findings in a study using whole body magnetic resonance imaging to assess anterior chest wall inflammation in patients with spondyloarthritis.

Research article   Open Access

Association between being African-American, serum urate levels and the risk of developing hyperuricemia: findings from the Coronary Artery Risk Development in Young Adults cohort

Angelo L Gaffo, David R Jacobs, Cora E Lewis, Ted R Mikuls, Kenneth G Saag Arthritis Research & Therapy 2012, 14:R4 (6 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis

Niklas Schuelert, Jason J McDougall Arthritis Research & Therapy 2012, 14:R5 (7 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: results of a phase I randomized, placebo-controlled trial

Brinda Emu, Diana Luca, Carolyn Offutt, Jane L Grogan, Bernadette Rojkovich, Marna B Williams, Meina T Tang, Jim Xiao, June H Lee, John C Davis Arthritis Research & Therapy 2012, 14:R6 (8 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

Dong Sohn, Jeremy Sokolove, Orr Sharpe, Jennifer C Erhart, Piyanka E Chandra, Lauren J Lahey, Tamsin M Lindstrom, Inyong Hwang, Katherine A Boyer, Thomas P Andriacchi, William H Robinson Arthritis Research & Therapy 2012, 14:R7 (8 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Identification and evaluation of novel synovial tissue biomarkers in rheumatoid arthritis by laser scanning cytometry

Christiane Fueldner, Anja Mittag, Jens Knauer, Maria Biskop, Pierre Hepp, Roger Scholz, Ulf Wagner, Ulrich Sack, Frank Emmrich, Attila Tárnok, Joerg Lehmann Arthritis Research & Therapy 2012, 14:R8 (17 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation

Asako Chiba, Miho Mizuno, Chiharu Tomi, Ryohsuke Tajima, Iraide Alloza, Alessandra di Penta, Takashi Yamamura, Koen Vandenbroeck, Sachiko Miyake Arthritis Research & Therapy 2012, 14:R9 (17 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Hyperuricemia and untreated gout are poor prognostic markers among those with a recent acute myocardial infarction

Eswar Krishnan, Bhavik J Pandya, Bharathi Lingala, Ali Hariri, Omar Dabbous Arthritis Research & Therapy 2012, 14:R10 (17 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Maraviroc, a chemokine receptor-5 antagonist, fails to demonstrate efficacy in the treatment of patients with rheumatoid arthritis in a randomized, double-blind placebo-controlled trial

Dona L Fleishaker, Juan A Garcia Meijide, Andriy Petrov, Michael Kohen, Xin Wang, Sujatha Menon, Thomas C Stock, Charles A Mebus, James M Goodrich, Howard B Mayer, Bernhardt G Zeiher Arthritis Research & Therapy 2012, 14:R11 (17 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access Highly Accessed

The distribution pattern of critically short telomeres in human osteoarthritic knees

Maria Harbo, Laila Bendix, Anne-Christine Bay-Jensen, Jesper Graakjaer, Kent Søe, Thomas L Andersen, Per Kjaersgaard-Andersen, Steen Koelvraa, Jean-Marie Delaisse Arthritis Research & Therapy 2012, 14:R12 (18 January 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

An increase in the number of cells with ultra short telomeres is associated with increased severity of osteoarthritis, proximity to the most damaged section of the joint, and with senescence.

Research article   Open Access

A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee

Dawn Doré, Jonathon de Hoog, Graham Giles, Changhai Ding, Flavia Cicuttini, Graeme Jones Arthritis Research & Therapy 2012, 14:R13 (18 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis

Seung-Jun Hwang, Bongkun Choi, Soon-Suk Kang, Jae-Ho Chang, Yong-Gil Kim, Yeon-Ho Chung, Dong Sohn, Min So, Chang-Keun Lee, William H Robinson, Eun-Ju Chang Arthritis Research & Therapy 2012, 14:R14 (20 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment

Kaisa E Happonen, Tore Saxne, Pierre Geborek, Maria Andersson, Anders A Bengtsson, Roger Hesselstrand, Dick Heinegård, Anna M Blom Arthritis Research & Therapy 2012, 14:R15 (20 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice

Liesbet Lodewyckx, Frédéric Cailotto, Sarah Thysen, Frank P Luyten, Rik J Lories Arthritis Research & Therapy 2012, 14:R16 (20 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Effect of in utero exposure to diethylstilbestrol on lumbar and femoral bone, articular cartilage, and the intervertebral disc in male and female adult mice progeny with and without swimming exercise

Sora Rowas, Rami Haddad, Rahul Gawri, Abdul Al Ma'awi, Lorraine E Chalifour, John Antoniou, Fackson Mwale Arthritis Research & Therapy 2012, 14:R17 (23 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Neutralization of IL-17 ameliorates uveitis but damages photoreceptors in a murine model of spondyloarthritis

Jelena M Kezic, Tibor T Glant, James T Rosenbaum, Holly L Rosenzweig Arthritis Research & Therapy 2012, 14:R18 (23 January 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology

Research article   Open Access

Restrictive pulmonary function is more prevalent in patients with ankylosing spondylitis than in matched population controls and is associated with impaired spinal mobility: a comparative study

Gunnhild Berdal, Silje Halvorsen, Désirée van der Heijde, Morten Mowe, Hanne Dagfinrud Arthritis Research & Therapy 2012, 14:R19 (25 January 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Reduced spinal mobility is associated with restrictive pulmonary function in patients with ankylosing spondylitis, emphasizing the importance of maintaining spinal flexibility in the management of the disease.

Research article   Open Access Highly Accessed

Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis

Dimitrios Makrygiannakis, Shankar Revu, Marianne Engström, Erik af Klint, Anthony P Nicholas, Ger JM Pruijn, Anca I Catrina Arthritis Research & Therapy 2012, 14:R20 (27 January 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Glucocorticoid reduced levels of protein citrullination and the enzyme peptidylargininedeiminase 4 (PAD4) in the joints of patients with rheumatoid arthritis, and this was matched by a decrease in visible signs of inflammation.

Research article   Open Access

A randomised controlled trial of a self-management education program for osteoarthritis of the knee delivered by health care professionals

Sophie Coleman, N Kathryn Briffa, Graeme Carroll, Charles Inderjeeth, Nicola Cook, Jean McQuade Arthritis Research & Therapy 2012, 14:R21 (27 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine

Elena Schiopu, Kristine Phillips, Paul M MacDonald, Leslie J Crofford, Emily C Somers Arthritis Research & Therapy 2012, 14:R22 (27 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes

Raghunatha R Yammani, Richard F Loeser Arthritis Research & Therapy 2012, 14:R23 (30 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

A profile of immune response to herpesvirus is associated with radiographic joint damage in rheumatoid arthritis

John M Davis, Keith L Knutson, John A Skinner, Michael A Strausbauch, Cynthia S Crowson, Terry M Therneau, Peter J Wettstein, Eric L Matteson, Sherine E Gabriel Arthritis Research & Therapy 2012, 14:R24 (31 January 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies

Chih Liu, Stephanie Tangsombatvisit, Jacob M Rosenberg, Gil Mandelbaum, Emily C Gillespie, Or P Gozani, Ash A Alizadeh, Paul J Utz Arthritis Research & Therapy 2012, 14:R25 (2 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis

David D McErlain, Veronica Ulici, Mark Darling, Joseph S Gati, Vasek Pitelka, Frank Beier, David W Holdsworth Arthritis Research & Therapy 2012, 14:R26 (3 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey

Ziver Sahin, Muge Bıcakcıgil, Kenan Aksu, Sevil Kamali, Servet Akar, Fatos Onen, Omer Karadag, Zeynep Ozbalkan, Askin Ates, Huseyin TE Ozer, Vuslat Yilmaz, Emire Seyahi, Mehmet A Ozturk, Ayse Cefle, Veli Cobankara, A Mesut Onat, Ercan Tunc, Nursen Düzgün, Sibel Z Aydin, Neslihan Yilmaz, İzzet Fresko, Yasar Karaaslan, Sedat Kiraz, Nurullah Akkoc, Murat Inanc, Gokhan Keser, F Aytul Uyar, Haner Direskeneli, Güher Saruhan-Direskeneli, the Turkish Takayasu Study Group et al. Arthritis Research & Therapy 2012, 14:R27 (6 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis

Scott W Graf, Sue Lester, Johannes C Nossent, Catherine L Hill, Susanna M Proudman, Anita Lee, Maureen Rischmueller Arthritis Research & Therapy 2012, 14:R28 (7 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis

Sindhuja M Rao, Jennifer L Auger, Philippe Gaillard, Ralph Weissleder, Etsuko Wada, Richard Torres, Masayasu Kojima, Christophe Benoist, Diane Mathis, Bryce A Binstadt Arthritis Research & Therapy 2012, 14:R29 (7 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Neuromedin U (NMU), a neuropeptide produced by bone-marrow-derived cells, promotes autoantibody-mediated arthritis in mice, suggesting NMU may be a potential therapeutic target in inflammatory arthritis.

Research article   Open Access

Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up

Mark Houseman, Catherine Potter, Nicola Marshall, Rachel Lakey, Tim Cawston, Ian Griffiths, Steven Young-Min, John D Isaacs Arthritis Research & Therapy 2012, 14:R30 (7 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access Highly Accessed

Direct transplantation of mesenchymal stem cells into the knee joints of Hartley strain guinea pigs with spontaneous osteoarthritis

Mitsuhiko Sato, Kenzo Uchida, Hideaki Nakajima, Tsuyoshi Miyazaki, Alexander Guerrero, Shuji Watanabe, Sally Roberts, Hisatoshi Baba Arthritis Research & Therapy 2012, 14:R31 (7 February 2012)

Abstract | Full text | PDF | PubMed | F1000

Research article   Open Access Highly Accessed

Atacicept in combination with MMF and corticosteroids in lupus nephritis: results of a prematurely terminated trial

Ellen M Ginzler, Stephen Wax, Anand Rajeswaran, Samuel Copt, Jan Hillson, Eleanor Ramos, Nora G Singer Arthritis Research & Therapy 2012, 14:R33 (7 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | F1000 Biology

Research article   Open Access Highly Accessed

Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis

Natalie A Carter, Elizabeth C Rosser, Claudia Mauri Arthritis Research & Therapy 2012, 14:R32 (8 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Serum levels of CXCL13 are associated with ultrasonographic synovitis and predict power Doppler persistence in early rheumatoid arthritis treated with non-biological disease-modifying anti-rheumatic drugs

Serena Bugatti, Antonio Manzo, Francesca Benaglio, Catherine Klersy, Barbara Vitolo, Monica Todoerti, Garifallia Sakellariou, Carlomaurizio Montecucco, Roberto Caporali Arthritis Research & Therapy 2012, 14:R34 (15 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles

Joyce JBC van Beers, Annemiek Willemze, Judith Stammen-Vogelzangs, Jan W Drijfhout, René EM Toes, Ger J M Pruijn Arthritis Research & Therapy 2012, 14:R35 (17 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis

Agneta Zickert, Karin Palmblad, Birgitta Sundelin, Sangeeta Chavan, Kevin J Tracey, Annette Bruchfeld, Iva Gunnarsson Arthritis Research & Therapy 2012, 14:R36 (20 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Serum levels of high mobility group box 1 protein (HMGB1) are significantly increased in patients with lupus nephritis and remain raised after the initiation of immunosuppressive therapy, possibly indicating persistent inflammatory activity.

Research article   Open Access

Erectile dysfunction is frequent in systemic sclerosis and associated with severe disease: a study of the EULAR Scleroderma Trial and Research group

Chingching Foocharoen, Alan Tyndall, Eric Hachulla, Edoardo Rosato, Yannick Allanore, Dominique Farge-Bancel, Paola Caramaschi, Paolo Airó, Starovojtova M Nikolaevna, José Pereira da Silva, Bojana Stamenkovic, Gabriela Riemekasten, Simona Rednic, Jean Sibilia, Piotr Wiland, Ingo Tarner, Vanessa Smith, Anna T Onken, Walid Abdel Atty Mohamed, Oliver Distler, Jadranka Morović-Vergles, Andrea Himsel, Paloma de la Peña Lefebvre, Thomas Hügle, Ulrich A Walker Arthritis Research & Therapy 2012, 14:R37 (20 February 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Severe erectile dysfunction is common amongst men with systemic sclerosis, appearing relatively early after disease diagnosis and associated with age; low treatment coverage suggests increased physician awareness is required.

Research article   Open Access Highly Accessed

Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway

Sang-il Lee, David L Boyle, Andres Berdeja, Gary S Firestein Arthritis Research & Therapy 2012, 14:R38 (21 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study

Jon T Giles, Justyna Fert-Bober, Jin Park, Clifton O Bingham, Felipe Andrade, Karen Fox-Talbot, Dimitrios Pappas, Antony Rosen, Jennifer van Eyk, Joan M Bathon, Marc K Halushka Arthritis Research & Therapy 2012, 14:R39 (24 February 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Research article   Open Access

Local delivery of AAV2-CTLA4IgG decreases sialadenitis and improves gland function in the C57BL/6.NOD-Aec1Aec2 mouse model of Sjögren's syndrome

Hongen Yin, Cuong Q Nguyen, Yuval Samuni, Toshimitsu Uede, Ammon B Peck, John A Chiorini Arthritis Research & Therapy 2012, 14:R40 (27 February 2012)

Abstract | Full text | PDF | PubMed

Research article   Open Access

Usage of skin care products and risk of rheumatoid arthritis: results from the Swedish EIRA study

Berit M Sverdrup, Henrik Källberg, Lars Klareskog, Lars Alfredsson, Epidemiological Investigation of Rheumatoid Arthritis Study Group Arthritis Research & Therapy 2012, 14:R41 (28 February 2012)

Abstract | Full text | PDF | PubMed


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