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Open Access Research article

Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

W Mark Erwin13*, Diana Islam3, Robert D Inman235, Michael G Fehlings234 and Florence WL Tsui35

Author Affiliations

1 University of Toronto and Toronto Western Hospital, Mc13-310, 399 Bathurst Street, Toronto M5T 2S8

2 Institute of Medical Science, 2374 Medical Sciences Building, 1 King's College Circle, University of Toronto, Toronto, Ontario, Canada, M5S 1A8

3 Toronto Western Research Institute, 399 Bathurst Street, Toronto M5T 2S8, Toronto Ontario, Canada

4 Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst St., WW 4-447, Toronto, ON M5T 2S8

5 Department of Immunology, Medical Sciences Building, Room 5271, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8

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Arthritis Research & Therapy 2011, 13:R215  doi:10.1186/ar3548

Published: 29 December 2011

Additional files

Additional file 1:

Figure S1: Activated caspase-3 activity in NP cells treated with IL-1β + FasL for 24 and 48 hours (expressed relative to untreated cells). There is a clear and significant induction of cleaved/activated caspase-3 in the 48-hour treatment group verifying the induction of apoptosis. This is the same trend observed with fluorescent activated cell sorting analysis using Annexin V and Propidium Iodide. (Y axis refers to luminescence units/hour).

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