High-fat diet promotes weight gain and hyperglycemia. Five-week-old male C57BL/6 mice were placed on either a high-fat (60% kcal) or low-fat (10% kcal) diet for 2 months before meniscal-ligamentous injury (MLI). Body weight (a) and blood glucose levels (b) were determined at monthly intervals after MLI. *P < 0.05; **P < 0.01; n = 5 to 9 mice at each time point.
Mooney et al. Arthritis Research & Therapy 2011 13:R198 doi:10.1186/ar3529