Table 5

Baseline characteristics of male OA patients according to serum FSTL1 levels.

Male serum FSTL1 levels (μg/L)


First quartile

Second quartile

Third quartile

Fourth quartile

P

r


(1.19-3.81)

(3.81-5.40)

(5.88-8.62)

(8.79-16.88)

Number

12

12

12

12

Age (years)

58 (47-61)

60 (54-74)

58 (52-72)

69 (65-79)

0.005

0.396

Disease duration (years)

0.1 (0.1-1.7)

0.6 (0.2-4.8)

1.5 (0.5-3.8)

2.5 (0.2-6.8)

0.004

0.405

Height, cm

170 (166-174)

168 (166-170)

166 (162-170)

169 (168-170)

0.378

-0.130

Weight, kg

72 (66-76)

68 (64-76)

67 (60-75)

69 (61-77)

0.376

-0.131

BMI

24.2 (22.8-26.2)

24.6 (22.7-26.3)

24.0 (21.6-25.8)

24.0 (21.4-26.4)

0.511

-0.097

Single/dual knee (hip)

11/1

12/0

9/3

9/3

0.130

0.222

Hypertension

4 (33%)

5 (42%)

5 (42%)

6 (50%)

0.486

0.103

Diabetes

2 (17%)

1 (8%)

1 (8%)

3 (25%)

0.687

0.060

Hs-CRP (mg/L)

1.4 (0.7-1.9)

1.1 (0.4-10.7)

1.4 (0.6-2.9)

2.4 (0.7-15.5)

0.056

0.278

ESRa

8 (3-10)

4 (3-13)

5 (5-20)

12 (2-27)

0.957

-0.009

RF

3.8 (0.3-10.6)

7.2 (4.8-18.7)

11.1 (6.0-18.8)

9.0 (7.4-16.3)

0.021

0.332

Pain (VAS mm)b

55 (40-60)

50 (20-70)

50 (35-80)

50 (40-80)

0.371

0.145

WOMAC score (all normalized/100)c

Pain subscale

64 (57-68)

64 (64-71)

60 (51-68)

59 (52-61)

0.407

-0.152

Stiffness subscale

58 (46-75)

61 (45-81)

49 (45-79)

54 (43-58)

0.636

-0.087

Function subscale

65 (54-83)

77 (46-90)

69 (35-90)

60 (52-65)

0.617

-0.092

Total Score

63 (55-85)

69 (51-80)

63 (44-78)

59 (52-63)

0.342

-0.168

KL grade (0-4)

5/4/2/0/2

4/2/3/1/2

3/1/5/1/2

2/2/4/1/3

0.069

0.265

JSN

2 (17%)

3 (25%)

3 (25%)

4 (33%)

0.127

0.224


Data are number (%) or median (25th to 75th percentile). Linear regression was used to evaluate the relationships between FSTL1 and baseline characteristics and to calculate P values and the correlation coefficient, r. (Serum FSTL1 levels, disease duration, hs-CRP, ESR and RF in the male OA patients were not normally distributed and were entered as ln-transformed variables). aData from ESR were available for 39 patients; bData for Pain VAS were available for 40 patients; cData from the total WOMAC score were available for 34 patients, and the pain subscale, stiffness subscale and function subscale were available for 32 patients, respectively. BMI, body mass index; ESR, erythrocyte sedimentation rate; FSTL1, follistatin-like protein 1; Hs-CRP, high sensitivity C-reactive protein; JSN, joint space narrowing; KL, Kellgren and Lawrence; OA, osteoarthritis; RF, rheumatoid factor; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities.

Wang et al. Arthritis Research & Therapy 2011 13:R193   doi:10.1186/ar3522

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