Table 5 |
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Baseline characteristics of male OA patients according to serum FSTL1 levels. |
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|
Male serum FSTL1 levels (μg/L) |
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|
|
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|
First quartile |
Second quartile |
Third quartile |
Fourth quartile |
P |
r |
|
|
|
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|
(1.19-3.81) |
(3.81-5.40) |
(5.88-8.62) |
(8.79-16.88) |
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|
Number |
12 |
12 |
12 |
12 |
||
|
Age (years) |
58 (47-61) |
60 (54-74) |
58 (52-72) |
69 (65-79) |
0.005 |
0.396 |
|
Disease duration (years) |
0.1 (0.1-1.7) |
0.6 (0.2-4.8) |
1.5 (0.5-3.8) |
2.5 (0.2-6.8) |
0.004 |
0.405 |
|
Height, cm |
170 (166-174) |
168 (166-170) |
166 (162-170) |
169 (168-170) |
0.378 |
-0.130 |
|
Weight, kg |
72 (66-76) |
68 (64-76) |
67 (60-75) |
69 (61-77) |
0.376 |
-0.131 |
|
BMI |
24.2 (22.8-26.2) |
24.6 (22.7-26.3) |
24.0 (21.6-25.8) |
24.0 (21.4-26.4) |
0.511 |
-0.097 |
|
Single/dual knee (hip) |
11/1 |
12/0 |
9/3 |
9/3 |
0.130 |
0.222 |
|
Hypertension |
4 (33%) |
5 (42%) |
5 (42%) |
6 (50%) |
0.486 |
0.103 |
|
Diabetes |
2 (17%) |
1 (8%) |
1 (8%) |
3 (25%) |
0.687 |
0.060 |
|
Hs-CRP (mg/L) |
1.4 (0.7-1.9) |
1.1 (0.4-10.7) |
1.4 (0.6-2.9) |
2.4 (0.7-15.5) |
0.056 |
0.278 |
|
ESRa |
8 (3-10) |
4 (3-13) |
5 (5-20) |
12 (2-27) |
0.957 |
-0.009 |
|
RF |
3.8 (0.3-10.6) |
7.2 (4.8-18.7) |
11.1 (6.0-18.8) |
9.0 (7.4-16.3) |
0.021 |
0.332 |
|
Pain (VAS mm)b |
55 (40-60) |
50 (20-70) |
50 (35-80) |
50 (40-80) |
0.371 |
0.145 |
|
WOMAC score (all normalized/100)c |
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|
Pain subscale |
64 (57-68) |
64 (64-71) |
60 (51-68) |
59 (52-61) |
0.407 |
-0.152 |
|
Stiffness subscale |
58 (46-75) |
61 (45-81) |
49 (45-79) |
54 (43-58) |
0.636 |
-0.087 |
|
Function subscale |
65 (54-83) |
77 (46-90) |
69 (35-90) |
60 (52-65) |
0.617 |
-0.092 |
|
Total Score |
63 (55-85) |
69 (51-80) |
63 (44-78) |
59 (52-63) |
0.342 |
-0.168 |
|
KL grade (0-4) |
5/4/2/0/2 |
4/2/3/1/2 |
3/1/5/1/2 |
2/2/4/1/3 |
0.069 |
0.265 |
|
JSN |
2 (17%) |
3 (25%) |
3 (25%) |
4 (33%) |
0.127 |
0.224 |
|
|
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|
Data are number (%) or median (25th to 75th percentile). Linear regression was used to evaluate the relationships between FSTL1 and baseline characteristics and to calculate P values and the correlation coefficient, r. (Serum FSTL1 levels, disease duration, hs-CRP, ESR and RF in the male OA patients were not normally distributed and were entered as ln-transformed variables). aData from ESR were available for 39 patients; bData for Pain VAS were available for 40 patients; cData from the total WOMAC score were available for 34 patients, and the pain subscale, stiffness subscale and function subscale were available for 32 patients, respectively. BMI, body mass index; ESR, erythrocyte sedimentation rate; FSTL1, follistatin-like protein 1; Hs-CRP, high sensitivity C-reactive protein; JSN, joint space narrowing; KL, Kellgren and Lawrence; OA, osteoarthritis; RF, rheumatoid factor; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities. |
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|
Wang et al. Arthritis Research & Therapy 2011 13:R193 doi:10.1186/ar3522 |
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