Table 3 |
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|
Baseline characteristics of female OA patients according to serum FSTL1 levels. |
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|
Female serum FSTL1 levels (μg/L) |
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|
|
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|
First quartile |
Second quartile |
Third quartile |
Fourth quartile |
P |
r |
|
|
|
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|
(1.94-15.65) |
(15.65-24.35) |
(24.45-31.08) |
(31.20-54.20) |
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|
Number |
30 |
30 |
30 |
30 |
||
|
Age (years) |
62 (52-67) |
66 (58-72) |
62 (56-70) |
61 (54-65) |
0.592 |
0.049 |
|
Disease duration (years) |
1 (0.5-3.0) |
1 (0.2-6.3) |
1.5 (0.5-3.6) |
2 (0.5-8.5) |
0.282 |
0.099 |
|
Height, cm |
160 (155-164) |
158 (156-162) |
158 (158-162) |
158 (155-162) |
0.049 |
-0.181 |
|
Weight, kg |
65 (60-70) |
62 (55-70) |
65 (60-70) |
60 (55-65) |
0.272 |
-0.101 |
|
BMI |
25.3 (22.9-27.1) |
25.1 (22.0-28.1) |
25.8 (24.3-27.5) |
23.9 (22.6-26.1) |
0.667 |
-0.040 |
|
Single/dual knee (hip) |
22/8 |
21/9 |
21/9 |
22/8 |
0.795 |
0.024 |
|
Hypertension |
10 (33%) |
9 (30%) |
12 (40%) |
6 (20%) |
0.309 |
-0.094 |
|
Diabetes |
5 (17%) |
2 (7%) |
6 (20%) |
2 (7%) |
0.894 |
-0.012 |
|
Hs-CRP (mg/L) |
1.4 (0.6-4.1) |
2.2 (1.1-4.7) |
1.9 (1.0-4.6) |
1.9 (0.9-11.3) |
0.113 |
0.146 |
|
ESRa |
13 (6-26) |
11 (8-20) |
10 (7-20) |
11 (5-20) |
0.270 |
-0.114 |
|
RF |
6.9 (2.7-12.9) |
8.6 (2.8-14.6) |
7.3 (3.1-12.7) |
7.7 (3.5-14.6) |
0.910 |
0.010 |
|
Pain (VAS mm)b |
60 (50-70) |
60 (50-78) |
55 (40-78) |
50 (36-70) |
0.166 |
-0.143 |
|
WOMAC score (all normalized/100)c |
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|
Pain subscale |
57 (50-61) |
57 (48-70) |
50 (46-64) |
61 (53-71) |
0.129 |
0.177 |
|
Stiffness subscale |
47 (42-56) |
50 (38-61) |
58 (42-71) |
64 (52-73) |
0.015 |
0.279 |
|
Function subscale |
56 (52-68) |
59 (50-68) |
63 (48-77) |
73 (58-90) |
0.079 |
0.204 |
|
Total Score |
56 (48-63) |
56 (48-66) |
61 (46-73) |
68 (56-78) |
0.051 |
0.214 |
|
KL grade (0-4) |
6/7/13/1/3 |
0/5/8/7/10 |
0/4/10/10/6 |
0/6/2/11/11 |
<0.0001 |
0.406 |
|
JSN |
4 (13%) |
17 (57%) |
16 (53%) |
22 (73%) |
<0.0001 |
0.419 |
|
|
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|
Data are number (%) or median (25th to 75th percentile). Linear regression was used to evaluate the relationships between FSTL1 levels and baseline characteristics and to calculate P values and the correlation coefficient, r. (Disease duration, hs-CRP, ESR and RF in the female OA patients were not normally distributed and were entered as ln-transformed variables). aData from ESR were available for 95 patients; bData from Pain VAS were available for 95 patients; cData from the total WOMAC score were available for 84 patients, and the pain subscale, stiffness subscale and function subscale were available for 75 patients, respectively. BMI, body mass index; ESR, erythrocyte sedimentation rate; FSTL1, follistatin-like protein 1; Hs-CRP, high sensitivity C-reactive protein; JSN, joint space narrowing; KL, Kellgren and Lawrence; OA, osteoarthritis; RF, rheumatoid factor; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities. |
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|
Wang et al. Arthritis Research & Therapy 2011 13:R193 doi:10.1186/ar3522 |
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