Table 3

Baseline characteristics of female OA patients according to serum FSTL1 levels.

Female serum FSTL1 levels (μg/L)


First quartile

Second quartile

Third quartile

Fourth quartile

P

r


(1.94-15.65)

(15.65-24.35)

(24.45-31.08)

(31.20-54.20)

Number

30

30

30

30

Age (years)

62 (52-67)

66 (58-72)

62 (56-70)

61 (54-65)

0.592

0.049

Disease duration (years)

1 (0.5-3.0)

1 (0.2-6.3)

1.5 (0.5-3.6)

2 (0.5-8.5)

0.282

0.099

Height, cm

160 (155-164)

158 (156-162)

158 (158-162)

158 (155-162)

0.049

-0.181

Weight, kg

65 (60-70)

62 (55-70)

65 (60-70)

60 (55-65)

0.272

-0.101

BMI

25.3 (22.9-27.1)

25.1 (22.0-28.1)

25.8 (24.3-27.5)

23.9 (22.6-26.1)

0.667

-0.040

Single/dual knee (hip)

22/8

21/9

21/9

22/8

0.795

0.024

Hypertension

10 (33%)

9 (30%)

12 (40%)

6 (20%)

0.309

-0.094

Diabetes

5 (17%)

2 (7%)

6 (20%)

2 (7%)

0.894

-0.012

Hs-CRP (mg/L)

1.4 (0.6-4.1)

2.2 (1.1-4.7)

1.9 (1.0-4.6)

1.9 (0.9-11.3)

0.113

0.146

ESRa

13 (6-26)

11 (8-20)

10 (7-20)

11 (5-20)

0.270

-0.114

RF

6.9 (2.7-12.9)

8.6 (2.8-14.6)

7.3 (3.1-12.7)

7.7 (3.5-14.6)

0.910

0.010

Pain (VAS mm)b

60 (50-70)

60 (50-78)

55 (40-78)

50 (36-70)

0.166

-0.143

WOMAC score (all normalized/100)c

Pain subscale

57 (50-61)

57 (48-70)

50 (46-64)

61 (53-71)

0.129

0.177

Stiffness subscale

47 (42-56)

50 (38-61)

58 (42-71)

64 (52-73)

0.015

0.279

Function subscale

56 (52-68)

59 (50-68)

63 (48-77)

73 (58-90)

0.079

0.204

Total Score

56 (48-63)

56 (48-66)

61 (46-73)

68 (56-78)

0.051

0.214

KL grade (0-4)

6/7/13/1/3

0/5/8/7/10

0/4/10/10/6

0/6/2/11/11

<0.0001

0.406

JSN

4 (13%)

17 (57%)

16 (53%)

22 (73%)

<0.0001

0.419


Data are number (%) or median (25th to 75th percentile). Linear regression was used to evaluate the relationships between FSTL1 levels and baseline characteristics and to calculate P values and the correlation coefficient, r. (Disease duration, hs-CRP, ESR and RF in the female OA patients were not normally distributed and were entered as ln-transformed variables). aData from ESR were available for 95 patients; bData from Pain VAS were available for 95 patients; cData from the total WOMAC score were available for 84 patients, and the pain subscale, stiffness subscale and function subscale were available for 75 patients, respectively. BMI, body mass index; ESR, erythrocyte sedimentation rate; FSTL1, follistatin-like protein 1; Hs-CRP, high sensitivity C-reactive protein; JSN, joint space narrowing; KL, Kellgren and Lawrence; OA, osteoarthritis; RF, rheumatoid factor; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities.

Wang et al. Arthritis Research & Therapy 2011 13:R193   doi:10.1186/ar3522

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