Table 1

SNP association analysis of the 18 SNPs in all cases and controls

Gene and SNP

Positiona

Minor allele

Minor allele frequency

P value

Corrected P valueb

Odds ratio (95% confidence interval)


Case

Control


FCGR3A

rs11581823

1:161517384

C

0.0830

0.0975

0.28

0.84 (0.62 to 1.14)

rs7539036

1:161512731

T

0.0580

0.0714

0.25

0.80 (0.56 to 1.14)

FCGR2A

rs4656308

1:161478751

C

0.1602

0.1456

0.36

1.12 (0.88 to 1.42)

rs1801274

1:161479745

G

0.3565

0.34

0.43

1.08 (0.90 to 1.29)

TNFAIP3

rs5029924

6:138187498

T

0.0817

0.0470

0.0017

0.030

1.80 (1.25 to 2.61)

rs5029937

6:138195151

T

0.0812

0.0448

0.0006

0.012

1.88 (1.30 to 2.73)

rs2230926

6:138196066

G

0.0811

0.0448

0.0007

0.012

1.88 (1.30 to 2.72)

rs610604

6:138199417

G

0.0989

0.0984

1.00

1.00 (0.75 to 1.34)

TLR9

rs187084

3:52261031

C

0.3773

0.3722

0.82

1.02 (0.85 to 1.22)

rs352140

3:52256697

A

0.3686

0.3635

0.82

1.02 (0.86 to 1.22)

rs352162

3:52252969

G

0.3850

0.3770

0.72

1.04 (0.87 to 1.24)

TREX1

rs2242150

3:48505964

A

0.3535

0.3340

0.35

1.09(0.91 to 1.31)

rs3135941

3:48507667

C

0.0326

0.0392

0.47

0.82 (0.52 to 1.32)

ETS1

rs6590330

11:128311059

A

0.4258

0.3086

3.0 × 10-8

5.5 × 10-7

1.66 (1.39 to 1.99)

rs4937333

11:128330520

T

0.4814

0.3652

9.3 × 10-8

1.7 × 10-6

1.61 (1.35 to 1.92)

TNIP1

rs13168551

5:150462638

T

0.2211

0.2505

0.14

0.85 (0.69 to 1.05)

rs7708392

5:150457485

G

0.2132

0.2587

0.02

0.39

0.78 (0.63 to 0.96)

rs10036748

5:150458146

C

0.2196

0.2552

0.08

0.82 (0.66 to 1.02)


Bold data are significant. aGenomic positions from NCBI Genome Build 37.1 (GRCh37) [56]. bP values calculated by Fisher's exact test and then corrected by the Bonferroni criterion.

Zhong et al. Arthritis Research & Therapy 2011 13:R186   doi:10.1186/ar3514

Open Data