Table 1 |
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|
Summary of significant differences detected (P < 0.05) among MZ twins discordant for SAID and unrelated, matched controls* |
|||||
|
Affected vs. unaffected twins |
|||||
|
|
|||||
|
Up-Regulated: |
Accession No. |
P-value |
Exp. Ratio |
Location |
Function |
|
α-1-antichymotrypsin precursor |
P01011 |
0.0008 |
1.37 |
Extracellular |
Protease inhibitor |
|
Syntaxin 17 |
P56962 |
0.0022 |
1.30 |
Plasma membrane |
Vesicular transport |
|
Keratin type II |
P35908 |
0.0040 |
1.26 |
Cytoplasm |
Structural |
|
Complement C8 precursor |
P07358 |
0.0070 |
1.14 |
Extracellular |
Immune response |
|
α-1-acid glycoprotein |
P02763 |
0.0073 |
1.42 |
Extracellular |
Acute phase reaction |
|
Retinoblastoma-binding protein 1 |
P29374 |
0.0117 |
1.53 |
Nucleus |
Transcriptional regulation |
|
Complement C4 precursor |
P01028 |
0.0122 |
1.36 |
Extracellular |
Immune response |
|
Plasma protease C1 inhibitor precursor |
P05155 |
0.0144 |
1.19 |
Extracellular |
Protease inhibitor |
|
Maltase-glucoamylase intestinal |
O43451 |
0.0167 |
1.51 |
Cytoplasm |
Carbohydrate catabolism |
|
Hematopoietic-specific transmembrane-4 protein |
Q96HJ5 |
0.0197 |
1.21 |
Plasma membrane |
Immune response |
|
Ubiquitin carboxyl-terminal hydrolase 29 |
Q9HBJ7 |
0.0271 |
1.44 |
Unknown |
Peptidase |
|
Complement C6 precursor |
P13671 |
0.0282 |
1.19 |
Extracellular |
Immune response |
|
Complement C9 precursor |
P02748 |
0.0390 |
1.18 |
Extracellular |
Immune response |
|
Kallikrein precursor |
P03952 |
0.0407 |
1.22 |
Extracellular |
Peptidase |
|
Myomesin 1 |
P52179 |
0.0418 |
1.27 |
Myofibers |
Structural |
|
Leucine-rich α-2-glycoprotein precursor |
P02750 |
0.0473 |
1.26 |
Extracellular |
pleiotropic** |
|
Down-Regulated: |
|||||
|
Serum paraoxonase/arylesterase 1 |
P27169 |
0.0195 |
0.82 |
Extracellular |
Detoxification/anti-oxidation |
|
Apolipoprotein A-II precursor |
P02652 |
0.0231 |
0.75 |
Extracellular |
Transporter |
|
Fetuin-A |
P02765 |
0.0278 |
0.79 |
Extracellular |
Protease inhibitor |
|
Minor histocompatibility antigen H13 |
Q8TCT9 |
0.0356 |
0.78 |
Endoplasmic reticulum |
Protease |
|
Affected Twins vs. Unrelated, Matched Controls |
|||||
|
Up-Regulated: |
|||||
|
Leucine-rich α-2-glycoprotein precursor |
P02750 |
0.0086 |
1.46 |
Extracellular |
pleiotropic** |
|
Fibrinogen β-precursor |
P02675 |
0.0109 |
1.33 |
Extracellular |
Coagulation |
|
Apolipoprotein C-IV precursor |
P55056 |
0.0155 |
1.69 |
Extracellular |
Transporter |
|
Apolipoprotein E precursor |
P02649 |
0.0193 |
1.24 |
Extracellular |
Transporter |
|
α-1-microglobulin/Inter-α-trypsin inhibitor |
P02760 |
0.0199 |
1.41 |
Extracellular |
Protease inhibitor |
|
Nuclear receptor co-activator 6 |
Q14686 |
0.0307 |
1.33 |
Nucleus |
Transcriptional regulation |
|
Plasma retinol-binding protein precursor |
P02753 |
0.0356 |
1.30 |
Extracellular |
Transporter |
|
Retinoblastoma-binding protein 1 |
P29374 |
0.0361 |
1.43 |
Nucleus |
Transcriptional regulation |
|
Apolipoprotein C-III precursor |
P02656 |
0.0395 |
1.29 |
Extracellular |
Transporter |
|
Kallistatin precursor |
P29622 |
0.0461 |
1.19 |
Extracellular |
Peptidase inhibitor |
|
Down-Regulated: |
|||||
|
Coagulation factor XII precursor |
P00748 |
0.0017 |
0.76 |
Extracellular |
Coagulation |
|
Peroxisomal carnitine octanoyl transferase |
Q9UKG9 |
0.0196 |
0.67 |
Peroxisome |
Metabolism fatty acid |
|
Ficolin 3 precursor |
NP_003656 |
0.0218 |
0.83 |
Extracellular |
Immune response |
|
Fibrinogen C |
NP_116232 |
0.0248 |
0.83 |
Extracellular |
Coagulation |
|
Probable ATP-dependent helicase DHX37 |
Q8IY37 |
0.0253 |
0.89 |
Nucleus |
RNA helicase |
|
Polycystin 1 precursor |
P98161 |
0.0341 |
0.78 |
Plasma membrane |
Transporter/Signaling |
|
Complement C1q A chain precursor |
P02745 |
0.0350 |
0.69 |
Extracellular |
Immune response |
|
NK cell receptor 3DL1 precursor |
P43629 |
0.0368 |
0.85 |
Plasma membrane |
Immune response |
|
Serum paraoxonase/arylesterase 1 |
P27169 |
0.0381 |
0.75 |
Extracellular |
Detoxification/anti-oxidation |
|
Unaffected Twins vs. Unrelated, Matched Controls |
|||||
|
Up-Regulated: |
|||||
|
Apolipoprotein C-IV precursor |
P55056 |
0.0436 |
1.38 |
Extracellular |
Transporter |
|
Apolipoprotein C-III precursor |
P02656 |
0.0493 |
1.24 |
Extracellular |
Transporter |
|
Histone deacetylase 3 |
O15379 |
0.0494 |
1.12 |
Nucleus |
Chromatin modulation |
|
Down-Regulated: |
|||||
|
Alpha-1-antichymotrypsin precursor |
P01011 |
0.0036 |
0.84 |
Extracellular |
Protease inhibitor |
|
Fibrinogen C |
NP_116232 |
0.0046 |
0.78 |
Extracellular |
Coagulation |
|
Ficolin 3 precursor |
NP_003656 |
0.0049 |
0.80 |
Extracellular |
Immune response |
|
Keratin type II |
P35908 |
0.0232 |
0.87 |
Cytoplasm |
Structural |
|
Syntaxin 17 |
P56962 |
0.0311 |
0.85 |
Plasma membrane |
Vesicular transport |
|
Serum paraoxonase/arylesterase 1 |
P27169 |
0.0466 |
0.69 |
Extracellular |
Detoxification/anti-oxidation |
|
|
|||||
|
*Abbreviations: No., number; Exp., expression **protein-protein interaction; cell adhesion; signal transduction; granulocyte differentiation |
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|
O'Hanlon et al. Arthritis Research & Therapy 2011 13:R181 doi:10.1186/ar3506 |
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