Table 1

Summary of significant differences detected (P < 0.05) among MZ twins discordant for SAID and unrelated, matched controls*

Affected vs. unaffected twins


Up-Regulated:

Accession No.

P-value

Exp. Ratio

Location

Function

α-1-antichymotrypsin precursor

P01011

0.0008

1.37

Extracellular

Protease inhibitor

Syntaxin 17

P56962

0.0022

1.30

Plasma membrane

Vesicular transport

Keratin type II

P35908

0.0040

1.26

Cytoplasm

Structural

Complement C8 precursor

P07358

0.0070

1.14

Extracellular

Immune response

α-1-acid glycoprotein

P02763

0.0073

1.42

Extracellular

Acute phase reaction

Retinoblastoma-binding protein 1

P29374

0.0117

1.53

Nucleus

Transcriptional regulation

Complement C4 precursor

P01028

0.0122

1.36

Extracellular

Immune response

Plasma protease C1 inhibitor precursor

P05155

0.0144

1.19

Extracellular

Protease inhibitor

Maltase-glucoamylase intestinal

O43451

0.0167

1.51

Cytoplasm

Carbohydrate catabolism

Hematopoietic-specific transmembrane-4 protein

Q96HJ5

0.0197

1.21

Plasma membrane

Immune response

Ubiquitin carboxyl-terminal hydrolase 29

Q9HBJ7

0.0271

1.44

Unknown

Peptidase

Complement C6 precursor

P13671

0.0282

1.19

Extracellular

Immune response

Complement C9 precursor

P02748

0.0390

1.18

Extracellular

Immune response

Kallikrein precursor

P03952

0.0407

1.22

Extracellular

Peptidase

Myomesin 1

P52179

0.0418

1.27

Myofibers

Structural

Leucine-rich α-2-glycoprotein precursor

P02750

0.0473

1.26

Extracellular

pleiotropic**

Down-Regulated:

Serum paraoxonase/arylesterase 1

P27169

0.0195

0.82

Extracellular

Detoxification/anti-oxidation

Apolipoprotein A-II precursor

P02652

0.0231

0.75

Extracellular

Transporter

Fetuin-A

P02765

0.0278

0.79

Extracellular

Protease inhibitor

Minor histocompatibility antigen H13

Q8TCT9

0.0356

0.78

Endoplasmic reticulum

Protease

Affected Twins vs. Unrelated, Matched Controls

Up-Regulated:

Leucine-rich α-2-glycoprotein precursor

P02750

0.0086

1.46

Extracellular

pleiotropic**

Fibrinogen β-precursor

P02675

0.0109

1.33

Extracellular

Coagulation

Apolipoprotein C-IV precursor

P55056

0.0155

1.69

Extracellular

Transporter

Apolipoprotein E precursor

P02649

0.0193

1.24

Extracellular

Transporter

α-1-microglobulin/Inter-α-trypsin inhibitor

P02760

0.0199

1.41

Extracellular

Protease inhibitor

Nuclear receptor co-activator 6

Q14686

0.0307

1.33

Nucleus

Transcriptional regulation

Plasma retinol-binding protein precursor

P02753

0.0356

1.30

Extracellular

Transporter

Retinoblastoma-binding protein 1

P29374

0.0361

1.43

Nucleus

Transcriptional regulation

Apolipoprotein C-III precursor

P02656

0.0395

1.29

Extracellular

Transporter

Kallistatin precursor

P29622

0.0461

1.19

Extracellular

Peptidase inhibitor

Down-Regulated:

Coagulation factor XII precursor

P00748

0.0017

0.76

Extracellular

Coagulation

Peroxisomal carnitine octanoyl transferase

Q9UKG9

0.0196

0.67

Peroxisome

Metabolism fatty acid

Ficolin 3 precursor

NP_003656

0.0218

0.83

Extracellular

Immune response

Fibrinogen C

NP_116232

0.0248

0.83

Extracellular

Coagulation

Probable ATP-dependent helicase DHX37

Q8IY37

0.0253

0.89

Nucleus

RNA helicase

Polycystin 1 precursor

P98161

0.0341

0.78

Plasma membrane

Transporter/Signaling

Complement C1q A chain precursor

P02745

0.0350

0.69

Extracellular

Immune response

NK cell receptor 3DL1 precursor

P43629

0.0368

0.85

Plasma membrane

Immune response

Serum paraoxonase/arylesterase 1

P27169

0.0381

0.75

Extracellular

Detoxification/anti-oxidation

Unaffected Twins vs. Unrelated, Matched Controls

Up-Regulated:

Apolipoprotein C-IV precursor

P55056

0.0436

1.38

Extracellular

Transporter

Apolipoprotein C-III precursor

P02656

0.0493

1.24

Extracellular

Transporter

Histone deacetylase 3

O15379

0.0494

1.12

Nucleus

Chromatin modulation

Down-Regulated:

Alpha-1-antichymotrypsin precursor

P01011

0.0036

0.84

Extracellular

Protease inhibitor

Fibrinogen C

NP_116232

0.0046

0.78

Extracellular

Coagulation

Ficolin 3 precursor

NP_003656

0.0049

0.80

Extracellular

Immune response

Keratin type II

P35908

0.0232

0.87

Cytoplasm

Structural

Syntaxin 17

P56962

0.0311

0.85

Plasma membrane

Vesicular transport

Serum paraoxonase/arylesterase 1

P27169

0.0466

0.69

Extracellular

Detoxification/anti-oxidation


*Abbreviations: No., number; Exp., expression

**protein-protein interaction; cell adhesion; signal transduction; granulocyte differentiation

O'Hanlon et al. Arthritis Research & Therapy 2011 13:R181   doi:10.1186/ar3506

Open Data