Molecular pathway analysis. Ingenuity Pathways Analysis was used to examine the differential expression values of the entire plasma protein datasets between SAID discordant MZ twins. Fischer's exact test was used to calculate a P-value determining the probability that the association between the markers in the dataset and the canonical pathway is attributable to chance alone (blue bars). The ratio of the number of genes from the dataset that map to a given pathway divided by the total number of markers that comprise the pathway is shown by the yellow line.
O'Hanlon et al. Arthritis Research & Therapy 2011 13:R181 doi:10.1186/ar3506