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Highly Accessed Review

Mechanisms of tissue injury in lupus nephritis

Tamara K Nowling12 and Gary S Gilkeson12*

Author affiliations

1 Department of Medicine, Division of Rheumatology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 912 MSC 637 Charleston, SC 29425-6370, USA

2 Medical Research Service, Ralph H. Johnson Veterans Affairs Medical Center, 109 Bee Street, Charleston, SC 29401, USA

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Citation and License

Arthritis Research & Therapy 2011, 13:250  doi:10.1186/ar3528

Published: 21 December 2011

Abstract

Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and human lupus patients.