Table 2

Interferon-regulated chemokines and other cytokines in adult and juvenile dermatomyositis subgroups compared with controls

Healthy controls

Adult DM subjects

Juvenile DM subjects

Median

(n = 26)

95% CI

Median

(n = 56)

95% CI

P value

Median

(n = 35)

95% CI

P value

IFN gene score^a

6.5 (n = 20)

4.2 to 13.0

16.7 (n = 51)

8.6 to 29.9

0.006

18.8

(n = 32)

10.3 to 52.0

0.001

IFN chemokine score^b

3.9

2.8 to 4.5

19.1

10.2 to 27.8

<0.0001

19.2

12.9 to 36.8

<0.0001

IP-10^c

40.4

34.1 to 47.1

1066.9

240.2 to 1816.2

<0.0001

881.9

427.9 to 2328.7

<0.0001

ITAC

29.0

22.6 to 39.6

202.6

101.0 to 376.0

<0.0001

190.8

112.3 to 593.2

<0.0001

MCP-1

339.1

280.3 to 430.6

954.8

630.9 to 1293.6

<0.0001

850.3

749.2 to 1285.5

<0.0001

Other chemokines and cytokines

MIP-1β

180.9

163.2 to 208.3

179.1

149.2 to 219.5

0.808

207.8

168.2 to 250

0.301

MIG

15.7

12.0 to 18.7

100.0

60.57 to 143.6

<0.0001

80.1

44.7 to 128.2

<0.0001

IL-6

1.1

1.2 to 1.5

3.4

2.5 to 5.6

<0.0001

5.3

3.2 to 9.5

<0.0001

IL-8

15.0

11.8 to 19.2

8.4

6.0 to 3.0

0.002

8.2

6.5 to 13.4

0.003

IL-10

2.3

1.6 to 5.4

1.7

1.1 to 2.8

0.082

3.2

1.3 to 6.7

0.903

TNFα

4.8

4.5 to 5.3

4.3

3.1 to 5.2

0.184

6.7

5.1 to 7.5

0.022

Significant P values (Mann-Whitney test P ≤ 0.05 for comparison against controls) presented in bold. CI, confidence interval; DM, dermatomyositis; IFN, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein. ^aCalculated using mean expression values of IFIT1, G1P2, and IRF7 measured by quantitative real-time RT-PCR. ^bCalculated using the normalized mean of IP-10, I-TAC, and MCP-1 levels in serum. ^cProtein levels are expressed as pg/ml.

Baechler et al. Arthritis Research & Therapy 2011 13:249   doi:10.1186/ar3531