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Review

Type I interferon pathway in adult and juvenile dermatomyositis

Emily C Baechler1, Hatice Bilgic1 and Ann M Reed2*

Author Affiliations

1 Division of Rheumatic and Autoimmune Diseases, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA

2 Division of Rheumatology, Department of Medicine and Pediatrics, Mayo Clinic, Rochester, MN 55905, USA

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Arthritis Research & Therapy 2011, 13:249  doi:10.1186/ar3531

Published: 22 December 2011

Abstract

Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.