Type I interferon pathway in adult and juvenile dermatomyositis
1 Division of Rheumatic and Autoimmune Diseases, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
2 Division of Rheumatology, Department of Medicine and Pediatrics, Mayo Clinic, Rochester, MN 55905, USA
Arthritis Research & Therapy 2011, 13:249 doi:10.1186/ar3531Published: 22 December 2011
Gene expression profiling and protein studies of the type I interferon pathway have revealed important insights into the disease process in adult and juvenile dermatomyositis. The most prominent and consistent feature has been a characteristic whole blood gene signature indicating upregulation of the type I interferon pathway. Upregulation of the type I interferon protein signature has added additional markers of disease activity and insight into the pathogenesis of the disease.